Archives: Solution Manual

e1 QUESTIONS 1. Compare the assays used to assess corrosivity and irritancy in skin substitute test systems. 2. Discuss the advantages of cryopreservation in the blasts and keratinocytes to skin test systems? 4. What value may skin test systems have […]

e1 QUESTIONS 1. Describe the tissue engineering paradigm as it relates to generating the myocardium. Consider the role of each component. 3. Describe the ideal properties of a scaffold for cardiac muscle engineering. Propose how you would develop such a […]

e1 EXERCISE You have been tasked with developing a synthetic bone graft for a young patient that has osteosarcoma of the femur. The patient is being treated with chemotherapy, and is scheduled to have the tumor removed in two which […]

e1 QUESTIONS 1. What are the advantages and disadvantages of cultur- ing cells on a scaffold using a bioreactor as compared to a conventional Petri dish? ANSWERS Advantages: • Perfusion of media provides sufficient nutrient supply inside the scaffold • […]

e1 QUESTIONS 1. Which material property was the basis for Charles b. hemocompatibility c. thermal stability d. viscoelasticity e. all of the above. 2. Silicone breast implants cause which of the following complications? a. breast cancer b. connective-tissue disease c. […]

e1 EXERCISES 1. List the major factors causing variability of drug absorption in the GI tract. ANSWERS 1. Absorption from drug formulations can be divided into physicochemical and physiological factors, with a large extent of interdependence. They may not work […]

e1 QUESTION In deciding between a non-degradable versus a degrad- able polymer for an implantable drug delivery system, what would you need to know before proceeding with the selection? List the questions would you have, includ- ing tests that would […]

e1 EXERCISES 1. List the factors that can determine if an injected depot delivery system will be successful. delivery systems? ANSWERS 1. Made with approved polymers, contain a low toxic- ity drug, a precise well-defined release profile is not needed, […]

e1 EXERCISES 1. What is one advantage of PEGylation of non-viral ANSWERS 1. Answers may vary. One possible answer is that the PEG may interfere with efficient cellular uptake or intracellular trafficking so slow deshielding results in more efficient gene […]

e1 QUESTION KEY POINTS FOR ANSWER: a. Absorbable – short-term security is all that is needed, difficult to retrieve suture after implantation (e.g., subcutaneous or within abdominal wall, to secure anastamosis), surgeries where a second procedure is not advised. d. […]

e1 QUESTIONS 1. Some of the technologies replace just the dermal or epidermal components of the skin while some replace both. What are the advantages of skin substitutes that just supply one component? What are the advantages of skin substitutes […]

e1 EXERCISES 1. What are the three fundamental requirements of a difference between these two mechanisms of charge transfer? 3. Explain the inherent trade-off between choosing an electrode with a large surface area versus choosing an electrode with a small […]

PROBLEMS Problem 1 Sound at the level of the tympanic membrane demon- strates a pressure peak at a frequency of 2.5 kHz in the human. Consider the boundary conditions of the ear Ip=πd 4 32 . canal and explain why […]

e1 QUESTIONS 1. What material would you choose for a deep brain trolyte interface. You do not have to model the tissue. Model only the interface. 2. Calculate the increase in charge injected by decreasing the frequency of a symmetric […]

e1 QUESTIONS 1. What are the advantages of IOL implantation over spectacles for correction of vision after removal of cataract? What other improvements have been 3. What is the rationale for foldable IOLs? Which fold- able soft hydrophobic materials are […]

e1 QUESTIONS 1. Classify the different types of chemical bonds within and between molecules (intra– and inter-molecular bonds. These can be expressed either as forces or as interaction energies. What is the relationship between these two physical quantities? Group these […]

e1 QUESTIONS 1. What are the general mechanical property qualifica- tions for orthopedic biomaterials, and what are the major categories of orthopedic implants? type involved in this process? 4. Name six of the primary orthopedic implant biomaterials. 5. Name one […]

e1 QUESTIONS 1. (a) What are the three most common implant alloys used in structural applications? For each one, state which element in the alloy is chosen to enhance 2. Consider a situation in which a 316L stainless steel fracture […]

e1 QUESTIONS 1. The two major mechanisms of chemical degradation of polymers in vivo are hydrolysis and oxidation. Given the following polymers, indicate whether they are susceptible to hydrolysis, oxidation or both pro- 2. What are some common polymer functional […]

e1 QUESTIONS 1. Why is the in vivo assessment of a medical device carried out? 2. What biomaterial components and characteristics may affect the overall biological responses of a medi- cal device? 6. Several different types of biocompatibility tests uti- […]

e1 QUESTIONS 1. Calculating share price, post money, and pre-money valuations. A new company needs to raise a $5,000,000 (series A) investment, and they are negotiating pre-money valu- ation with a venture firm. They also expect to require b. Assume […]

e1 QUESTIONS 1. For an implanted biocompatible biomaterial, iden- tify the characteristic cell types and response dura- tion of the following responses: a . Acute inflammation b. Chronic inflammation 2. List the three classes of substances released by mac- rophages […]

e1 HOMEWORK PROBLEMS 1. Draw diagrams of the emulsification processes used to create polymer microparticles (e.g., O/W, W/O, 2. Quantum dots have been widely used for imaging, particularly of cells and biomolecules. Describe some of the benefits quantum dots have […]

e1 EXERCISES 1. Think of a materials-related problem in biomedical engineering, for which there exists no current good solution: is there something that you wish a material 2. Identify an “Olympian feat” performed by a natural material (where the term […]

e1 QUESTIONS 1. Briefly define the following, using examples where applicable: a. angiogenesis b. osteointegration c. stress shielding d. enucleation 2. Name two medical device applications in which textured or porous materials/coatings are used. Describe how the surfaces were rendered […]

e1 QUESTIONS 1. You are assigned the task of designing a proteomics array to the surface of a standard, glass microscope slide in a 25 × 25 array. Design a scheme to make to spray-coat the device. When it is […]

e1 QUESTIONS 1. How would you construct a ligament prosthesis? ANSWERS 1. Any design should take into account the specific requirements. The main requirement of a ligament is to transmit loads between the two bones to which it is connected. […]

e1 QUESTIONS 1. Alginic acid is a polysaccharide derived from algae and is commonly used in foods, for cell encapsula- 2. Chondroitin sulfate (CS) is a naturally-occurring glycosaminoglycan abundant in cartilage and is commonly sourced from animal cartilage or shark […]

e1 QUESTIONS 1. The transformation of a solid implant into water-sol- uble material(s) is best described by the term “bioero- sion”. Which of the following events may or may not accompany bioerosion? (a) Changes in the physico-mechanical properties of the […]

e1 QUESTIONS 1. Name at least four mechanisms that may hold a hydrogel together without covalent bonds. side groups on the network chains degrade; (c) their chains lose hydrophobically-bound water; or (d) their ionic groups are protonated. 3. pH-responsive, carboxylated […]

e1 PROBLEMS 1. Which of the following HAP ceramics do you believe would be the most successful in repairing a bone defect made by the excision of a large tumor in a weight-bearing bone, and why? 2. The ASTM mandates […]

e1 QUESTIONS 1. Teflon™ is often called “inert.” Is it biologically inert? Explain. 2. The node-fibrillar morphology of ePTFE is critical to certain performances. Explain why. ANSWERS 1. All fluoropolymers react with biological components, so they are not biologically inert. […]

e1 QUESTIONS 1. Draw the molecular structure represented by the shorthand notation D5. What is its chemical name? 2. What functions can fillers serve in silicone elastomers? a. material extender to reduce bulk cost 3. Describe at least two of […]

e1 QUESTIONS 1. One powerful chemical species is the isocyanates group. In this chapter we have discovered that the iso- cyanates group is important in the synthesis of poly- 2. Polyurethanes are important biomaterials; however, these polymers are also commercially […]

e1 QUESTIONS 1. This question is related to your knowledge of how chemical structure affects a polymer’s glass transition temperature. For each pair below draw the repeat unit of the polymers, select which polymer you believe has a higher glass […]

e1 QUESTIONS 1. The following statements characterize, in part, the goals and specific aims of an implant retrieval and evaluation program. Answer True or False. a. Determine rates, modes, and mechanisms of implant failure; b. Identify effects of patient and […]

e1 QUESTIONS 1. Overview of major terminal sterilization modalities: a. What are the two dominant sterilization modalities? b. Why do so many device companies use them? c. What are their major safety concerns? 2. Please provide brief descriptions of: a. […]

PROBLEMS 1. What are the three main driving forces that affect the competitive adsorption of proteins to biomaterials from complex mixtures such as blood plasma? 2. Calculate the amount of adsorbed protein in a close packed monolayer for an average […]

e1 QUESTIONS 1. Scan the table of contents and abstracts from the last three issues of the Journal of Biomedical Materials Research or Biomaterials. List all the surface analy- sis methods used in the articles therein and briefly describe what […]

e1 EXERCISES 1. What is the difference between: • resilience and toughness • toughness and fracture toughness • bulk modulus and shear modulus • nominal stress and normal stress 2. The net potential energy between two adjacent ions can be […]

e1 CHAPTER I.1.2 The Nature of Matter and Materials QUESTIONS 1. Which types of intermolecular forces dominate the assembly of atoms and molecules into matter for each of these types of materials? (a) butter. 2. Consider Figure I.1.2.6 in this […]

decision making and transactional requirements first. For one thing, they are easier to do and provide immediate payoffs. For another, these systems provide data that can be fed into higher-level planning systems. Copyright © 2016 Pearson Education, Inc. 1. An […]

Copyright © 2016 Pearson Education, Inc. environment—for example, one teller trying to service 100 customers an hour—then the simulation results will reflect that environment. That said, simulation models can help guide decision-makers to better solutions via “what if” analyses. multiple […]

Question 1 Question 2 Question 3 DFM and DfSC are related in that they are both focused creating a repeatable process for product development and manufacturing. DfSC is focused on creating a repeatable process for product standardize the processes parts […]

communication between all groups so that issues can be worked out together. Sequential development may be preferable if there is not general agreement on the characteristics of the new product at the beginning of the process. If this is the […]

a.) NOTE: Enter values from the problem into the yellow highlighted columns to find the solution: A 3 None 0 3 0 3 YES B 2 None 0 2 4.5 6.5 b.) Paths: Length: A-D-F-G 12 B-D-E-G 10 B-D-F-G 11 […]

that would place less value on project management skills would be ones that focus on routine activities such as a restaurant or retail store. Although even these businesses would have projects occuring now and then. Project management skills are good […]

*** Problem Set Key — Do Not Post or Distribute *** Chapter 14: Managing Projects Introduction to Operations & Supply Chain Management (Bozarth & Handfield, 3rd Edition) DIRECTIONS To generatethe key, put in the same 4-digit number used in printing […]