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e1
QUESTIONS
1. For an implanted biocompatible biomaterial, iden-
tify the characteristic cell types and response dura-
tion of the following responses:
a . Acute inflammation
b. Chronic inflammation
2. List the three classes of substances released by mac-
rophages and foreign-body giant cells that facilitate
the degradation of foreign materials.
3. Describe the process involved in the formation of
foreign-body giant cells.
7. What are the two most probable causes of finding
chronic inflammation at the tissue/implant interface
six weeks following implantation of a biomaterial?
8. What cell type and its product form the fibrous
capsule?
12. What cell death process does not promote an inflam-
matory response?
c . Infiltrating fibroblasts, new blood capillary for-
mation, 7–21 days
d. Macrophages and foreign-body giant cells, per sistent
e . Fibroblasts and collagen, persistent.
2. a . Oxygen radicals: ROIs – reactive oxygen interme-
c . Acid: pH between 3.5 and 7.2.
3. Monocytes migrate from blood vessels into the
implant site and adhere to the surface of the implant
where they differentiate into macrophages that fuse
to form multinucleated giant cells.
b. Size of implant
c . Shape of implant
d. Surface area of implant
e . Topography of implant
f . Chemical properties of the biomaterial
9. Myofibroblast.
10. a . Regeneration – replacement of injured tissue by
parenchymal cells of the same type.
b. Replacement – connective tissue formation, scar
CHAPTER II.2.2
Inflammation, Wound Healing,
and the Foreign-Body Response
