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e1
QUESTIONS
1. What are the advantages and disadvantages of cultur-
ing cells on a scaffold using a bioreactor as compared
to a conventional Petri dish?
ANSWERS
Advantages:
• Perfusion of media provides sufficient nutrient
supply inside the scaffold
and in vivo outcomes.
Disadvantages:
• More complex set-up
in representing in vivo conditions, the more pre-
dictive physiologic cell behavior can be accom-
plished. In order to mimic physiologic conditions,
the biomaterials scientist must thoroughly under-
ing development. Successful bioreactors should be
smartly designed to allow for adaptation on devel-
opmental tissue environments both spatially and
temporally.
• Introduction of good laboratory practice (GLP)
protocols. This relates to the complexity of regu-
The design constraints of surgical techniques and
the operating theater will likely pose additional
challenges to bioreactor design. The challenge
CHAPTER II.6.6
Bioreactors for Tissue Engineering
