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e1
EXERCISES
1. List the major factors causing variability of drug
absorption in the GI tract.
ANSWERS
1. Absorption from drug formulations can be divided
• Physiological factors include variability in gastric
emptying and colon transit, gastric pH, and pos-
ture. Physiological parameters are also influenced
2. Areas for drug targeting are:
(a) the upper gastrointestinal tract, using the stomach as
Strategies to achieve this are usually based on
gastroretentive technologies which use floatation or
obstruction to retain the material in the stomach.
(b) the lower small intestinal tract and colon, to achieve
chronotherapeutics or access to the bowel.
Access to temporal and spatial targets requires
CHAPTER II.5.16.G
Oral Drug Delivery
