168
Handout 9-3: Selected Herbal and Other Dietary Supplements
Marketed for Weight Loss
Bitter orange a (Citrus
aurantium, a natural flavoring
that contains synephrine, a
compound structurally similar
Stimulates weight loss;
provides an alternative
to ephedra
Little evidence available
May increase blood
pressure; may interact with
drugs
Conjugated linoleic acid
(CLA; a group of fatty acids
related to linoleic acid, but
with different cis– and trans–
configurations)
Reduces body fat and
suppresses appetite
Some evidence in animal
studies, modest fat loss in
human studies
ingredient derived from the
rind of the tropical fruit
Inhibits the enzyme that
converts citric acid to
fat; suppresses appetite
Toxicity symptoms
reported in animal studies;
headaches, respiratory and
gastrointestinal distress in
Ephedrine c (amphetamine–
like substance derived from
the Chinese ephedra herb ma
Short-term weight loss
and dangerous side effects
Insomnia, tremors, heart
attacks, strokes, and death;
FDA has banned the sale of
Pyruvate f (3-carbon
compound produced during
glycolysis)
Modest weight loss with
high doses
Yohimbine (derived from the
bark of a West African tree)
Nervousness, insomnia,
anxiety, dizziness, tremors,
headaches, nausea,
vomiting, hypertension
a Marketed under the trade names Xenadrine EFX, Metabolife Ultra, NOW Diet Support.
b Marketed under the trade names Chitorich, Exofat, Fat Breaker, Fat Blocker, Fat Magnet, Fat Trapper, and Fatsorb.
to epinephrine)
Chromium (trace mineral)
Eliminates body fat
Ineffective; weight gain
reported when not
accompanied by exercise
Headaches, sleep
disturbances, and mood
swings; hexavalent form is