Campbell Biology, 10e (Reece)
Chapter 42 Circulation and Gas Exchange
1) The circulatory systems of bony fishes, rays, and sharks are most similar to _____.
A) those of birds, with a four-chambered heart
B) the portal systems of mammals, where two capillary beds occur sequentially, without passage
of blood through a pumping chamber
C) those of sponges, where gas exchange in all cells occurs directly with the external
environment
D) those of humans, where there are four pumping chambers to drive blood flow
2) Organisms with a circulating body fluid that is distinct from the fluid that directly surrounds
the body’s cells are likely to have _____.
A) an open circulatory system
B) a closed circulatory system
C) a gastrovascular cavity
D) branched tracheae
3) In which of the following organisms does blood flow from the pulmocutaneous circulation to
the heart before circulating through the rest of the body?
A) annelids
B) fishes
C) frogs
D) insects
4) The only vertebrates in which blood flows directly from respiratory organs to body tissues
without first returning to the heart are the _____.
A) amphibians
B) fishes
C) mammals
D) reptiles
5) To adjust blood pressure independently in the capillaries of the gas-exchange surface and in
the capillaries of the general body circulation, an organism would need a(n) _____.
A) open circulatory system
B) hemocoel
C) two-chambered heart
D) four-chambered heart
6) An anthropologist discovers the fossilized heart of an extinct animal. The evidence indicates
that the organism’s heart was large, was well-formed, and had four chambers, with no connection
between the right and left sides. A reasonable conclusion supported by these observations is that
the _____.
A) animal had evolved from birds
B) animal was endothermic and had a high metabolic rate
C) animal was most closely related to alligators and crocodiles
D) species had little to no need to regulate blood pressure
7) In an open circulatory system, blood is _____.
A) always inside of vessels and is under higher pressure than in closed circulatory systems
B) not always confined to blood vessels and is under higher pressure than in closed circulatory
systems
C) always inside of vessels and is under lower pressure than in closed circulatory systems
D) not always confined to blood vessels and is under lower pressure than in closed circulatory
systems
8) Circulatory systems compensate for _____.
A) temperature differences between the lungs and the active tissue
B) the slow rate at which diffusion occurs over large distances
C) the problem of communication systems involving only the nervous system
D) the need to cushion animals from trauma
9) Which of the following develops the greatest pressure on the blood in the mammalian aorta?
A) systole of the left atrium
B) diastole of the right ventricle
C) systole of the left ventricle
D) diastole of the right atrium
10) Which of the following is the correct sequence of blood flow in birds and mammals?
A) left ventricle → aorta → lungs → systemic circulation
B) vena cava → right atrium → right ventricle → pulmonary vein
C) pulmonary vein → left atrium → left ventricle → pulmonary circuit
D) vena cava → right atrium → right ventricle → pulmonary artery
11) A patient with a blood pressure of 120/75, a pulse rate of 70 beats/minute, a stroke volume of
70 mL/beat (milliliters per beat), and a respiratory rate of 25 breaths/minute will have a cardiac
output of _____.
A) 1,000 mL/minute
B) 1,750 mL/minute
C) 2,800 mL/minute
D) 4,900 mL/minute
12) Damage to the sinoatrial node in humans _____.
A) would block conductance between the bundle branches and the Purkinje fibers
B) would have a negative effect on peripheral resistance
C) would disrupt the rate and timing of cardiac muscle contractions
D) would have a direct effect on blood pressure monitors in the aorta
13) A stroke volume of 70 mL/cycle in a heart with a pulse of 72 cycles per minute results in a
cardiac output of about _____.
A) 5 liters per minute
B) 50 milliliters per minute
C) 0.5 liters per minute
D) 50 liters per minute
14) Atria contract _____.
A) just prior to the beginning of diastole
B) during diastole
C) immediately after systole
D) during systole
15) The greatest difference in the concentration of respiratory gases is found in which of the
following pairs of mammalian blood vessels?
A) the pulmonary vein and the jugular vein
B) the veins from the right and left legs
C) the pulmonary artery and the inferior vena cava
D) the pulmonary vein and the aorta
16) A human red blood cell in an artery of the left arm is on its way to deliver oxygen to a cell in
the thumb. To travel from the artery to the thumb and then back to the left ventricle, this red
blood cell must pass through _____.
A) one capillary bed
B) two capillary beds
C) three capillary beds
D) four capillary beds
17) If a molecule of carbon dioxide released into the blood in your left toe is exhaled from your
nose, it must pass through all of the following EXCEPT _____.
A) the pulmonary vein
B) an alveolus
C) the trachea
D) the right atrium
18) Among the following choices, which organism likely has the highest systolic pressure?
A) mouse
B) human
C) hippopotamus
D) giraffe
19) The velocity of blood flow is the lowest in capillaries because _____.
A) the capillaries have internal valves that slow the flow of blood
B) the diastolic blood pressure is too low to deliver blood to the capillaries at a high flow rate
C) the systemic capillaries are supplied by the left ventricle, which has a lower cardiac output
than the right ventricle
D) the total cross-sectional area of the capillaries is greater than the total cross-sectional area of
the arteries or any other part of the circulatory system
20) A species that has a normal resting systolic blood pressure of greater than 260 mm Hg is
likely to be _____.
A) an animal that is small and compact, without the need to pump blood very far from the heart
B) a species that has very wide diameter veins
C) an animal that has a very long distance between its heart and its brain
D) an animal that makes frequent, quick motions
21) Small swollen areas in the neck, groin, and axillary region are associated with _____.
A) increased activity of the immune system
B) blood sugar that is abnormally high
C) dehydration
D) sodium depletion
22) What will be the long-term effect of blocking the lymphatic vessels associated with a
capillary bed?
A) more fluid entering the venous capillaries
B) an increase in the blood pressure in the capillary bed
C) the accumulation of more fluid in the interstitial areas
D) the area of the blockage becoming abnormally small
23) Which of the following conditions would most likely be due to high blood pressure in a
mammal?
A) bursting of blood vessels in capillary beds
B) inability of the right ventricle to contract
C) reversal of normal blood flow direction in arteries
D) destruction of red blood cells
24) Which of the following mechanisms are used to regulate blood pressure in the closed
circulatory system of vertebrates?
I) changing the force of heart contraction
II) constricting and relaxing sphincters in the walls of arterioles
III) adjusting the volume of blood contained in the veins
A) only I and II
B) only I and III
C) only II and III
D) I, II, and III
25) Blood is pumped at high pressures in arteries from the heart to ensure that all parts of the
body receive adequate blood flow. Capillary beds, however, would hemorrhage under direct
arterial pressures. How does the design of the circulatory network contribute to reducing blood
pressure to avoid this scenario?
A) Blood flow through the capillaries is essentially frictionless, and this reduces the amount of
pressure on their walls.
B) The total cross-sectional diameter of the arterial circulation increases with progression from
artery to arteriole to capillary, leading to a reduced blood pressure.
C) Fluid loss from the arteries is high enough that pressure drops off significantly by the time
blood reaches the capillaries.
D) Capillary beds have the thickest walls of any blood vessel to resist these high pressures.
Lymph hearts are pumping structures that drive lymph through the lymphatic system, returning it
to the circulatory system at the large veins entering the heart. Researchers examined rate and
strength of pumping of lymph hearts in two species of amphibians, a toad (Bufo marinus) and a
frog (Rana catesbiana). During hemorrhage or dehydration, the volume of blood in the
circulatory system falls. (E. A. DeGrauw and S. S. Hillman. 2004. General function and
endocrine control of the posterior lymph hearts in Bufo marinus and Rana catesbiana.
Physiological and Biochemical Zoology 77(4):594-600.)
26) Refer to the paragraph on lymph hearts. What effect would increasing lymph heart pressure
have first?
A) Blood volume would increase.
B) Blood volume would decrease.
C) Hemorrhage would increase.
D) Hemorrhage would decrease.
27) If, during protein starvation, the osmotic pressure on the venous side of capillary beds drops
below the hydrostatic pressure, then _____.
A) hemoglobin will not release oxygen
B) fluids will tend to accumulate in tissues
C) the pH of the interstitial fluids will increase
D) plasma proteins will escape through the endothelium of the capillaries
28) Large proteins such as albumin remain in capillaries rather than diffusing out, resulting in the
_____.
A) loss of osmotic pressure in the capillaries
B) development of an osmotic pressure difference across capillary walls
C) loss of fluid from capillaries
D) increased diffusion of hemoglobin
29) The production of red blood cells is stimulated by _____.
A) low-density lipoproteins
B) immunoglobulins
C) erythropoietin
D) epinephrine
30) To become bound to hemoglobin for transport in a mammal, atmospheric molecules of
oxygen must cross _____.
A) one membrane—that of the lining in the lungs—and then bind directly to hemoglobin, a
protein dissolved in the plasma of the blood
B) two membranes—in and out of the cell lining the lung—and then bind directly to hemoglobin,
a protein dissolved in the plasma of the blood
C) four membranes—in and out of the cell lining the lung, in and out of the endothelial cell
lining an alveolar capillary—and then bind directly to hemoglobin, a protein dissolved in the
plasma of the blood
D) five membranes—in and out of the cell lining the lung, in and out of the endothelial cell
lining an alveolar capillary, and into the red blood cell—to bind with hemoglobin
31) The diagnosis of hypertension in adults is based on the _____.
A) measurement of fatty deposits on the endothelium of arteries
B) measurement of the LDL/HDL ratio in peripheral blood
C) percentage of blood volume made up of platelets
D) blood pressure being greater than 140 mm Hg systolic and/or greater than 90 mm Hg diastolic
32) Cyanide poisons mitochondria by blocking the final step in the electron transport chain.
Human red blood cells placed in an isotonic solution containing cyanide are likely to _____.
A) retain the normal cell shape, but the mitochondria will be poisoned
B) lyse as the cyanide concentration increases inside the cell
C) switch to anaerobic metabolism
D) be unaffected
33) A normal event in the process of blood clotting is the _____.
A) production of erythropoietin
B) conversion of fibrin to fibrinogen
C) activation of prothrombin to thrombin
D) synthesis of hemoglobin
34) You cut your finger, and after putting pressure on the wound for several minutes, you notice
that it is still bleeding profusely. What may be the problem?
A) Platelets are not functioning properly, or there are too few to be effective.
B) Mast cells are not releasing their chemical messengers.
C) There are too many antigens to allow clotting.
D) Hemoglobin levels are too high to allow clotting.
35) The hormone that stimulates the production of red blood cells, and the organ where this
hormone is synthesized, are _____.
A) growth hormone and pancreas, respectively
B) erythropoietin and kidney, respectively
C) cortisol and adrenal gland, respectively
D) acetylcholine and bone marrow, respectively
36) Countercurrent exchange is evident in the flow of _____.
A) water across the gills of a fish and the blood within those gills
B) blood in the dorsal vessel of an insect and that of air within its tracheae
C) air within the primary bronchi of a human and the blood within the pulmonary veins
D) water across the skin of a frog and the blood flow within the ventricle of its heart
37) Countercurrent exchange in the fish gill helps to maximize _____.
A) blood pressure
B) diffusion
C) active transport
D) osmosis
38) Which of the following statements comparing respiration in fish and in mammals is correct?
A) The respiratory medium for fish carries more oxygen than the respiratory medium of
mammals.
B) A countercurrent exchange mechanism between the respiratory medium and blood flow is
seen in mammals but not in fish.
C) The movement of the respiratory medium in mammals is bidirectional, but in fish it is
unidirectional.
D) In blood, oxygen is primarily transported by plasma in fish, but by red blood cells in
mammals.
39) Flying insects typically _____.
A) decrease metabolism as much as 200-fold during flight
B) switch from diffusion of tracheal gases to active transport during flight
C) utilize high numbers of mitochondria in flight muscles
D) generate fuel molecules from catabolism of carbon dioxide
40) When the air in a testing chamber is specially mixed so that its oxygen content is 10 percent
and its overall air pressure is 400 mm Hg, then is _____.
A) 400 mm Hg
B) 82 mm Hg
C) 40 mm Hg
D) 4 mm Hg
41) The sun shining on a tidal pool during a hot day heats the water. As some water evaporates,
the pool becomes saltier, causing _____.
A) an increase in its carbon dioxide content
B) a decrease in its oxygen content
C) an increase in its ability to sustain aerobic organisms
D) a decrease in the water’s density
42) An oil-water mixture works as an insecticidal spray against mosquitoes and other insects
because it _____.
A) blocks the openings into the tracheal system
B) interferes with gas exchange across the capillaries
C) clogs their bronchi
D) prevents gases from leaving the atmosphere
43) Atmospheric pressure at sea level is equal to a column of 760 mm Hg. Oxygen makes up 21
percent of the atmosphere by volume. The partial pressure of oxygen ( ) in such conditions is
_____.
A) 160 mm Hg
B) 16 mm Hg
C) 21/760
D) 760/21
44) Some human infants, especially those born prematurely, suffer serious respiratory failure
because of _____.
A) the sudden change from the uterine environment to the air
B) the overproduction of surfactants
C) lung collapse due to inadequate production of surfactant
D) mutations in the genes involved in lung formation
45) At the summit of a high mountain, the atmospheric pressure is 380 mm Hg. If the
atmosphere is still composed of 21percent oxygen, then the partial pressure of oxygen at this
altitude is about _____.
A) 80 mm Hg
B) 160 mm Hg
C) 380 mm Hg
D) 760 mm Hg
46) Compared with the interstitial fluid that bathes active muscle cells, blood reaching these
muscle cells in arteries has a _____.
A) higher
B) greater bicarbonate concentration
C) lower pH
D) lower osmotic pressure
47) A rabbit taken from a meadow near sea level and moved to a meadow high on a
mountainside would have some trouble breathing. Why?
A) The percentage of oxygen in the air at high elevations is lower than at sea level.
B) The percentage of oxygen in the air at high elevations is higher than at sea level.
C) The partial pressure of oxygen in the air at high elevations is lower than at sea level.
D) The partial pressure of oxygen in the air at high elevations is higher than at sea level.
48) What would be the consequences if we were to reverse the direction of water flow over the
gills of a fish, moving water inward past the operculum, past the gills, the out the mouth? This
reversal of water flow would _____.
A) reduce efficiency of gas exchange
B) change the exchange of gases in the body from carbon dioxide out and oxygen in to carbon
dioxide in and oxygen out
C) increase the efficiency of gas exchange
49) Under identical atmospheric conditions, freshwater _____.
A) has more oxygen than seawater
B) has less oxygen than seawater
C) can hold 10-40 times more carbon dioxide than air
D) can hold 10-40 times more oxygen than air
50) Which of the following statements comparing respiration in fish and in mammals is correct?
A) The respiratory medium for fish carries more oxygen than the respiratory medium of
mammals.
B) A countercurrent exchange mechanism between the respiratory medium and blood flow is
seen in mammals but not in fish.
C) The movement of the respiratory medium in mammals is bidirectional, but in fish it is
unidirectional.
D) In blood, oxygen is primarily transported by plasma in fish, but by red blood cells in
mammals.
51) How has the avian lung adapted to the metabolic demands of flight?
A) Airflow through the avian lung is bidirectional like in mammals.
B) There is more dead space within the avian lung so that oxygen can be stored for future use.
C) Countercurrent circulation is present in the avian lung.
D) Gas exchange occurs during both inhalation and exhalation.
52) Carbon dioxide levels in the blood and cerebrospinal fluid affect pH. This enables the
organism to sense a disturbance in gas levels as _____.
A) the brain directly measures and monitors oxygen levels and causes breathing changes
accordingly
B) the medulla oblongata, which is in contact with cerebrospinal fluid, monitors pH and uses this
measure to control breathing
C) the brain alters the pH of the cerebrospinal fluid to force the animal to retain more or less
carbon dioxide
D) stretch receptors in the lungs cause the medulla oblongata to speed up or slow breathing
53) A person with a tidal volume of 450 mL (milliliters), a vital capacity of 4000 mL, and a
residual volume of 1000 mL would have a potential total lung capacity of _____.
A) 1450 mL
B) 4000 mL
C) 4450 mL
D) 5000 mL
54) During most daily activities, the human respiration rate is most closely linked to the blood
levels of _____.
A) nitrogen
B) oxygen
C) carbon dioxide
D) carbon monoxide
55) An decrease from pH 7.4 to pH 7.2 causes hemoglobin to _____.
A) release all bound carbon dioxide molecules
B) bind more oxygen molecules
C) increase its binding of H+
D) give up more of its oxygen molecules
56) The Bohr shift on the oxygen-hemoglobin dissociation curve is produced by changes in
_____.
A) the partial pressure of oxygen
B) hemoglobin concentration
C) temperature
D) pH
57) Most of the carbon dioxide produced by humans is _____.
A) converted to bicarbonate ions by an enzyme in red blood cells
B) bound to hemoglobin
C) transported in the erythrocytes as carbonic acid
D) simply dissolved in the plasma
58) Which of the following events would be predicted by the Bohr shift effect as the amount of
carbon dioxide released from your tissues into the blood capillaries increases? The amount of
oxygen in _____.
A) arterial blood would increase
B) arterial blood would decrease
C) venous blood would increase
D) venous blood would decrease
59) You are a physician, and you are seeing a patient who complains of abnormal fatigue during
exercise. You find that the immediate problem is a buildup of carbon dioxide in the tissues. What
is the most likely cause?
A) abnormally shaped platelets
B) abnormal carbonic anhydrase
C) abnormal hemoglobin
D) not enough hemoglobin
60) Carbonic anhydrase inhibitors cause less movement of carbonic acid toward carbon dioxide
production and are used as a prophylactic treatment of altitude sickness. Altitude sickness occurs
when a hiker ascends to altitudes where the density of oxygen is low. How does this decrease the
symptoms of high altitude sickness?
A) The excess hydrogen ions are excreted in the urine and the resulting loss of acidity increases
respiration rate.
B) The excess bicarbonate ions are excreted in the urine and the resulting loss of blood pressure
increases respiration rate.
C) The excess bicarbonate ions are excreted in the urine and the resulting increase in blood
acidity leads to an increase in ventilation.
D) The excess bicarbonate ions in the blood increase the affinity of hemoglobin for oxygen.