Menopause
Declines in key sex hormones are clearly implicated in the set of changes called menopause in women,
which literally means the cessation of the menses. Estrogen and progesterone are closely involved in
Menopausal Phases
Menopause, like puberty, is often thought of as a single event. It actually occurs, however, over several
years, and researchers generally agree that it consists of three phases.
During the premenopausal phase, estrogen levels begin to fluctuate and decline, typically in the late 30s
or early 40s, producing irregular menstrual periods in many women. The ovaries are less sensitive to
During the perimenopausal phase, estrogen levels decrease and women experience more extreme
variations in the timing of their menstrual cycles. The majority of women in the period of menopause
experience hot flashes. Symptoms include the sensation of warmth in the upper body and head, an abrupt
rise in skin temperature, increased heart rate, flushing, and usually visible sweating. The cause of hot
flashes is not known, but it must clearly be linked in some complex way to the drop in the level of
estrogen.
Eventually, estrogen and progesterone drop to consistently low levels, and menstruation ceases altogether.
Once a woman has ceased to menstruate for a year, she is in the postmenopausal phase. Estradiol and
Feature Box Activity (Learning Objective 15.2, p. 379)
No Easy Answers: The Pros and Cons of Hormone Therapy
What do you think? Do the risks of hormone therapy outweigh the advantages? Explain your answer.
Psychological Effects of Menopause
It has been part of folklore that menopause involves major emotional upheaval, as well as clear physical
changes. Such findings, however, are mixed. Depressive symptoms increase during menopause, but
serious depression is no more frequent among menopausal women than among those who are not
menopausal.