Chapter 19 ■ PRACTICAL APPLICATIONS 543
Chapter Nineteen
PRACTICAL APPLICATIONS
Name: ______________________________
A. Case Study
The patient is a 63-year-old woman with a history (10 years ago) of squamous cell carcinoma
in situ of the cervix, which was treated with a total abdominal hysterectomy. Three years ago a
pelvic mass was palpated, and exploratory laparotomy revealed a multinodular solid cystic mass
of 10 to 12 cm. The mass arose from the right ovary and was adherent to the right pelvic wall.
The patient underwent resection of the mass, and the pathology revealed squamous cell carcinoma
of the ovary. She subsequently had combined modality treatment with chemotherapy (cisplatin and
5-fluorouracil) and radiation therapy to the pelvis. The latest CT scan of the abdomen revealed a new
right retroperitoneal lymph node. CT-guided fine needle aspiration was consistent with metastatic
ovarian squamous cell carcinoma.
1. What best describes the patient’s
original diagnosis? …………………………
A. Endometrial and cervical carcinoma
B. Localized cancer of the lower portion of
the uterus
C. Cervical cancer that spread to the
abdomen
D. Ovarian cancer
2. What was the initial primary
treatment? ……………………………………
A. Drug treatment
B. Radiation treatment
C. Drug and radiation treatment
D. Surgical removal of the entire uterus
3. What procedure identified the new
pelvic mass? …………………………………
A. Incision of the abdomen
B. Radiation therapy
C. Total abdominal hysterectomy
D. CT scan of the abdomen
4. Which treatment modalities were
used for the patient’s ovarian
carcinoma? …………………………………..
A. Computed tomography of the abdomen
B. Fine-needle aspiration of the ovary
C. Drug and radiation therapy in addition to
surgical removal
D. Surgical resection of the mass
5. How would you characterize the
disease in the patient’s retroperitoneal
lymph node? …………………………………
A. Cancer of the lymphatic system
B. Cervical cancer that had spread
C. Primary ovarian cancer
D. Ovarian cancer that had spread
B. Research Report
In a recent trial comparing the antiemetics ondansetron (Zofran) and metoclopramide (Reglan),
ondansetron was more effective and produced less severe side effects. The trial involved 24 medical
centers and 307 cancer patients receiving high doses of cisplatin.
1. What type of drug is
ondansetron? ………………………………..
A. Chemotherapeutic
B. Antipsychotic medication
C. Antibiotic
D. Antinauseant
2. When is ondansetron
prescribed? …………………………………..
A. After cancer surgery
B. In conjunction with metoclopramide
C. When patients are receiving high-dose
chemotherapy for cancer
D. Before cancer surgery