Hall: Guyton and Hall Textbook of Medical Physiology, 12th Edition
Chapter 36: Hemostasis and Blood Coagulation
Test Bank
1. What is the proper pathway for the extrinsic clotting pathway?
A. Contact of blood with collagen, formation of prothrombin activator, conversion of
prothrombin into thrombin, conversion of fibrinogen into fibrin threads
B. Tissue trauma, formation of prothrombin activator, conversion of prothrombin into
thrombin, conversion of fibrinogen into fibrin threads
C. Activation of platelets, formation of prothrombin activator, conversion of
D. Prothrombin into thrombin, conversion of fibrinogen into fibrin threads.
E. Trauma to the blood, formation of prothrombin activator, conversion of
F. Prothrombin into thrombin, conversion of fibrinogen into fibrin threads
2. What condition leads to a deficiency in factor IX that can be corrected by an intravenous
injection of vitamin K?
A. Classic hemophilia
B. Hepatitis B
C. Bile duct obstruction
D. Genetic deficiency in antithrombin III
3. A 2-year-old boy bruises easily and has a history of nosebleeds. His physical examination
shows several small bruises on the legs. You would suspect that this patient has a
deficiency of which coagulation factor?
A. Prothrombin activator
B. Factor II
C. Factor VIII
D. Factor X
4. Which one of the following substances cannot prevent coagulation when added to a
blood sample (i.e., in the test tube)?
A. Heparin
B. Coumarin
C. Citrate
D. Calcium chelators
5. All of the following statements regarding heparin are correct EXCEPT:
A. Heparin acts by increasing the effectiveness of antithrombin III
B. The concentration of heparin in the blood is normally very slight
C. Heparin can be an effective anticoagulant even in the absence of antithrombin III
D. Heparin is a powerful anticoagulant
E. Heparin can be produced and released by basophils and mast cells
6. Which of the following is a function of thrombin?
A. Activation of factor XIII to stabilize fibrinolysis
B. Conversion of factor VII to VIIa
C. Conversion of fibrinogen to fibrin
D. Enhancement of factor V, VIII, and XI activity
7. What is the purpose of the PT test in monitoring hemostasis?
A. Measures factors of the extrinsic pathway
B. Detects platelet dysfunction
C. Detects presence of aspirin
D. Monitors heparin function
8. A patient presents with a platelet count of 212 x 103/µL and a bleeding time of 12
minutes. These results suggest:
A. Decreased platelet production
B. Defective platelet function
C. Increased platelet production
D. Increased platelet destruction
9. Which of the following will not result in an increased bleeding tendency?
A. Liver disease
B. Vitamin A deficiency
C. Warfarin overdose
D. Chronic aspirin medication
10. The excessive bleeding of a hemophiliac A (classical hemophilia) is usually caused by:
A. An excessive endogenous secretion of heparin
B. A genetic lack of factor VIII
C. An inability to absorb vitamin K
Test Bank
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D. A moderate thrombocytopenia
E. A genetic lack of factor IX
11. In a disorder called scurvy:
A. Bleeding abnormalities are unusual
B. Plasma ascorbic acid levels are usually decreased
C. Factor VIII is decreased
D. A dietary Vitamin C deficiency is the cause