Chapter 18 – Genomics
Chapter 18
Genomics
Multiple Choice Questions
1. The inclusive term that describes all of the DNA in the nucleus of a cell is its
Check All That Apply Questions
2. Every cell within one organism has the same genome. In what way(s) can these cells differ
from each other?
Multiple Choice Questions
3. The relative location of genes on a chromosome as determined by recombination
frequencies is illustrated in a map.
Chapter 18 – Genomics
4. Using actual landmarks within DNA sequences, scientists can generate a _______ map.
5. Distances on a genetic map are measured in _____ units.
6. Silent copies of genes that have been inactivated by mutations are called
Chapter 18 – Genomics
7. A human gene is composed of numerous fragments of protein-encoding information
known as _______.
8. The ends of chromosomes are called ________.
9. Mobile bits of DNA that can jump from one location on a chromosome to another location
are called
Chapter 18 – Genomics
10. Sequences of DNA assembled by identifying overlaps among smaller DNA segments are
known as
11. Conserved arrangements of segments of DNA in related genomes are referred to as
12. Mitochondria and chloroplasts are bacterial relatives living within eukaryotes as a result
of
Chapter 18 – Genomics
13. A defining characteristic of draft sequences is that they have
14. Your research team has been asked to quantify levels of cellular RNAs in rats before and
after exercise. The primary focus of your work will be to analyze the
Chapter 18 – Genomics
Clarify Question
•
What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about the transcriptome?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 18 – Genomics
15. A transgene is best described as
16. Long interspersed elements (LINES) are a type of
17. Non-coding DNA regions within a gene are referred to as
Chapter 18 – Genomics
Check All That Apply Questions
18. In your research, you are comparing the transcriptome and the proteome for two related
species. One gene in species B has a similar transcript but a much smaller protein than in
species A, and the protein seems to be nonfunctional. What do you predict about this gene?
(Select all that apply)
Clarify Question
•
What type of thinking is required?
Gather Content
•
What do you already know about pseudogenes?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 18 – Genomics
Multiple Choice Questions
19. A large portion (45%) of the human genome is composed of
20. Some regions of chromosomes remain highly condensed, tightly coiled, and
untranscribed throughout the cell cycle. These regions are referred to as
21. Linkage disequilibrium is the tendency for
Chapter 18 – Genomics
22. Microarrays are created by robotically placing DNA on to a microscope slide and probing
with
23. To avoid confusion and facilitate ease of data interpretation, researchers working on
cloned DNA from the same species use
24. The sequencing method that cuts DNA segments into fragments, arranges those
fragments based on overlapping nucleotide sequences, and then clones these fragments is
called
Chapter 18 – Genomics
25. The sequencing method that cuts the DNA of an entire chromosome into small fragments
and then clones these fragments is called
26. When comparing the genomes of prokaryotes verse eukaryotes, it can be accurately stated
that
27. The majority of DNA in a human can be described as
Chapter 18 – Genomics
28. Rice and its grain relatives, maize, barley, and wheat, diverged from a common ancestor
50 million years ago. However, the chromosomes of these plants demonstrate extensive
conserved arrangements of segments. This phenomenon is called
29. Groups of related, but distinctly different genes that appear to have arisen from a single
ancestral gene are referred to as
30. Identical copies of genes that can be transcribed simultaneously are called
Chapter 18 – Genomics
31. Recombination frequency between genes can be used to generate a
32. You are studying a novel protein. To learn more about it, you performed a screen in yeast
to identify proteins that could interact with it. From the screen you got a clone for a second
gene. You had the clone sequenced, and you translated the gene sequence on your computer.
What is the next logical step to learn more about the function of these two proteins?
Chapter 18 – Genomics
Clarify Question
•
What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about sequence analysis?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Chapter 18 – Genomics
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
33. Given a sequencing reaction length of approximately 500 successive nucleotides, what is
the absolute minimum number of sequencing reactions needed to determine the complete
human genome, excluding overlap and redundancy?