Introduction to General, Organic & Biological Chemistry, 12e (Timberlake)
Chapter 17 Nucleic Acids and Protein Synthesis
17.1 Multiple-Choice Questions
1) A ________ consists of a nitrogen-containing base and a sugar.
A) nucleoside
B) base pair
C) nucleotide
D) complementary base
E) pyrimidine
2) A ________ consists of a nitrogen-containing base, a sugar, and a phosphate group.
A) nucleoside
B) base pair
C) nucleotide
D) complementary base
E) purine
3) Which of the following cannot be found in a nucleotide of RNA?
A) purine
B) pyrimidine
C) phosphate
D) ribose
E) deoxyribose
4) Which of the following is found in RNA but not in DNA?
A) thymine
B) uracil
C) guanine
D) cytosine
E) deoxyribose
5) Which of the following will not be found in DNA?
A) adenine
B) thymine
C) guanine
D) cytosine
E) ribose
6) Which of the following can be found in DNA?
A) ribose
B) GMP
C) uracil
D) deoxyadenosine
E) FMN
7) The interactions that link the nucleotides in a nucleic acid are
A) ionic bonds
B) peptide bonds
C) hydrogen bonds
D) hydrophobic bonds
E) phosphodiester bonds
8) The nucleotides in the backbone of DNA are held together by ________ bonds.
A) hydrogen
B) peptide
C) phosphodiester
D) glycosidic
E) ionic
9) The unique sequence of bases in a nucleic acid is called the ________ structure.
A) ionic
B) primary
C) secondary
D) tertiary
E) quaternary
10) The base sequence of the strand of DNA complementary to the segment
-T G G C A A C- is:
A) -T G G C A A C-
B) -A C C G T T G-
C) -A C C G U U G-
D) -U C C G T T G-
E) -A C G C T U G-
11) The bonds that link the base pairs in the DNA double helix are ________.
A) ionic bonds
B) peptide bonds
C) hydrogen bonds
D) hydrophobic interactions
E) ester bonds
12) The two new DNA molecules formed in replication ________.
A) are different from the original DNA
B) both contain only two new daughter DNA strands
C) both contain only the parent DNA strands
D) contain one parent and one daughter strand
E) are identical, with one containing both parent strands, and the other containing both daughter
strands
13) What is the process in which the DNA double helix unfolds, and each strand serves as a
template for the synthesis of a new strand?
A) transcription
B) complementation
C) translation
D) replication
E) restriction
14) When DNA replicates, a guanine forms a base pair with ________.
A) uracil
B) adenine
C) guanine
D) thymine
E) cytosine
15) The two strands of the double helix of DNA are held together by ________.
A) hydrogen bonds
B) covalent bonds
C) dipole-dipole interactions
D) ionic bonds
E) sugar-to-phosphate bonds
16) In the synthesis of mRNA, an adenine in the DNA pairs with ________.
A) uracil
B) adenine
C) guanine
D) thymine
E) cytosine
17) Which of the following types of RNA carries the genetic information from DNA in the
nucleus to the ribosomes?
A) mRNA
B) histone RNA
C) rRNA
D) tRNA
E) sRNA
18) The base sequence of the DNA template strand is -T G C A A C-. What is the corresponding
mRNA?
A) -T G C A A C-
B) -A C G U U G-
C) –A C C U U G-
D) -U C G T T G-
E) -U C G T T C-
19) In transcription, ________.
A) the mRNA produced is identical to the parent DNA
B) a double helix containing one parent strand and one daughter strand is produced
C) uracil pairs with thymine
D) both strands of the DNA are copied
E) the mRNA produced is complementary to one strand of the DNA
20) Which of the following is a section of mRNA produced from the DNA template below?
-A T A G C T A-
A) -A T A G C T A-
B) -A U A G C U A-
C) -U A U C G A U-
D) -U U U G C U U-
E) -T A T C G A T-
21) Which one of the following base pairs is found in DNA?
A) adenine-thymine
B) adenine-guanine
C) cytosine-thymine
D) adenine-uracil
E) guanine-uracil
22) A DNA template having the base sequence -A G A T G A- would produce a mRNA with a
base sequence of ________.
A) -A G A T G A-
B) -U C U A C U-
C) -T C T U C T-
D) -T C T A C A-
E) -A C A U C A-
23) Codons are base pair sequences that ________.
A) signal the start of DNA synthesis
B) signal the end of DNA synthesis
C) code for amino acids
D) signal the start of RNA synthesis
E) code for one or more bases in mRNA
24) When mRNA is synthesized using the information from DNA, the process is called
________.
A) transportation
B) transposition
C) transcription
D) translation
E) transliteration
25) The codon is found on ________, and the anticodon is found on ________.
A) mRNA, tRNA
B) tRNA, mRNA
C) rRNA, tRNA
D) ribosomes, tRNA
E) mRNA, rRNA
26) The anticodon is ________.
A) identical to the codon on DNA
B) complementary to the codon on DNA
C) identical to the codon on mRNA
D) complementary to the codon on mRNA
E) complementary to the codon on tRNA
27) During protein synthesis, the codon for an amino acid is found on ________.
A) DNA
B) rRNA
C) tRNA
D) mRNA
E) sRNA
28) The anticodon of UAG is ________.
A) ATC
B) UAG
C) AAC
D) AUC
E) GAU
29) The codon UGA codes for ________.
A) Phe
B) Tyr
C) Start
D) Met
E) Stop
30) Translation is the process whereby ________.
A) DNA is synthesized from DNA
B) DNA is synthesized from mRNA
C) protein is synthesized from DNA
D) protein is synthesized from mRNA
E) mRNA is synthesized from DNA
31) What tripepetide is coded for by the following mRNA sequence? -UUU AGA CCA-
A) Phe-Pro-Arg
B) Pro-Arg-Phe
C) Phe-Arg-Pro
D) Leu-Pro-Arg
E) Phe-Thr-Pro
32) Mutations are the result of ________.
A) alterations in the phosphate of the DNA backbone
B) exposure to water in utero
C) physical trauma in the mother’s childhood
D) alterations in the sugar component of the DNA backbone
E) alterations in the DNA base sequence
33) The result of a defective enzyme caused by a mutation in the DNA nucleotide sequence is
________.
A) a genetic disease
B) AIDS
C) HIV
D) recombinant DNA
E) translocation
34) When a mutation occurs by elimination of one base in a DNA sequence, this mutation is
called a ________.
A) frameshift mutation
B) insertion mutation
C) substitution mutation
D) translocation mutation
E) viral mutation
35) A mutation which occurs when one base in a DNA sequence replaces another, is called a
________.
A) frameshift mutation
B) insertion mutation
C) substitution mutation
D) translocation mutation
E) viral mutation
36) Small living particles, with 3 to 200 genes, that cannot replicate without a host cell are called
________.
A) recombinant DNAs
B) viruses
C) bacteria
D) tumors
E) plasmids
37) A virus that contains RNA as its genetic material is a ________.
A) genetically engineered virus
B) bacteria
C) recombinant DNA
D) retrovirus
E) vaccine
38) Protease inhibitors, which are effective anti-HIV drugs, ________.
A) are nucleoside analogs
B) prevent reverse transcription
C) prevent synthesis of viral proteins
D) prevent mRNA synthesis
E) prevent activation of tRNA
1) Adenine is a purine.
2) Uracil is a pyrimidine.
3) A nucleotide consists of only a base and a sugar.
4) One of the differences between DNA and RNA is the sugar it contains.
5) The unique sequence of bases in a nucleic acid is the secondary structure.
6) Nucleotides are linked by phosphodiester bonds.
7) The sequence of bases in a nucleic acid is the secondary structure.
8) The DNA complement of the sequence -G C C A T- is -G C C A T-.
9) DNA is a protein.
10) In the DNA double helix, a purine can only pair with a pyrimidine.
11) mRNA codons contain three “letters.”
12) The stop codon terminates protein synthesis.
13) Messenger RNA carries protein synthesis information from the nucleus to the ribosomes.
14) The codon UUU codes for phenylalanine.
15) The codon AGA codes for serine.
16) The process of translocation involves the synthesis of mRNA.
17) The start codon is AUG.
18) Down syndrome is an acquired disease, not a genetic disease.
19) AZT is a drug used in the treatment of cancer.
20) A retrovirus uses DNA as its genetic material.
17.3 Matching Questions
Match the following.
A) tRNA
B) mRNA
C) rRNA
D) DNA
1) picks up the specific amino acids for protein synthesis
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.
2) synthesized by the DNA to carry the genetic message to the ribosomes
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.
3) contains within the nucleus of the cell the information for the synthesis of protein
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.
4) the nucleic acid that contains the codons for the amino acids of a protein
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.
5) the most abundant nucleic acid in the ribosomes
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.
6) the nucleic acid that contains a single anticodon for a specific amino acid
Page Ref: 17.4
Learning Obj.: 17.4
Global Outcomes: G7 Demonstrate the ability to make connections between concepts across
chemistry.