Hall: Guyton and Hall Textbook of Medical Physiology, 12th Edition
Chapter 17: Local and Humoral Control of Tissue Blood Flow
Test Bank
1. A healthy 25-year-old male medical student has an exercise stress test at a local health
club. Which of the following set of physiological changes is most likely to occur in this
man’s skeletal muscles during exercise?
Arteriole Diameter Adenosine Concentration Tissue Metabolism
A.
B.
C.
D.
E.
F.
G.
H.
2. The arterial pressure of an isolated perfused muscle is increased from 100 to 140 mmHg.
Blood flow to the muscle at 100 mmHg is 5 ml/min/100 g and 5.1 ml/min/100 g at 140
mmHg. The maintenance of blood flow despite the large elevation in arterial pressure is
due to an increase in which of the following?
A. arterial conductance
B. adenosine concentration
C. arteriolar resistance
D. lactic acid concentration
E. nitric oxide concentration
3. Autoregulation of tissue blood flow in response to an increase in arterial pressure occurs
as a result of
A. a decrease in vascular resistance
B. an initial decrease in vascular wall tension
C. excess delivery of nutrients such as oxygen to the tissues
D. a decrease in tissue metabolism
Test Bank
17-2
4. Histamine is injected into the brachial artery of a 25-year-old man. Which of the
following sets of changes would be expected to occur in response to histamine?
Vascular Vascular Capillary
Resistance Conductance Filtration
A.
B.
C.
D.
E.
5. A 72-year-old male had surgery to remove an abdominal tumor. Pathohistological studies
reveal that the tumor mass contains a large number of vessels. An increase in which of
the following is the most likely stimulus for the growth of vessels in a solid tumor?
A. growth hormone
B. plasma glucose concentration
C. angiostatin growth factor
D. tissue oxygen concentration
E. vascular endothelial growth factor
6. An increase in shear stress in a blood vessel would result in which of the following
changes?
A. decreased endothelin production
B. increased cyclic GMP production
C. decreased nitric oxide release
D. increased renin production
E. decreased prostacyclin production
7. Reducing arterial pressure in a muscle artery from 100 to 80 mmHg would result
A. in a long-term reduction in blood flow
B. in a reduction in arteriole diameter and increase in blood flow
C. a reduction in arteriole resistance and maintenance of normal blood flow
D. a decrease in vascular conductance
8. The diameter of a precapillary arteriole is increased in a muscle vascular bed. A decrease
in which of the following would be expected?
A. capillary filtration rate
B. vascular conductance
C. capillary blood flow
Test Bank
17-3
D. capillary hydrostatic pressure
E. arteriole resistance
9. A decrease in tissue metabolism results in
A. an decrease in arteriole resistance
B. an increase in arteriole diameter
C. an increase in capillary hydrostatic pressure
D. decrease in nutrient delivery to the tissues and tissue blood flow
10. Which one of the following would tend to decrease blood flow?
A. an increase in tissue carbon dioxide concentration
B. an increase in tissue lactic acid concentration
C. an increase in tissue metabolism
D. an increase in tissue oxygen concentration
11. Exercising on a treadmill results in significant increases in skeletal blood flow. A change
in which of the following sets of muscle tissue concentrations is the most likely
explanation for the increases in muscle blood flow?
Carbon Dioxide pH Adenosine
A.
B.
C.
D.
E.
F.
G.
H.