Chapter 16 – Control of Gene Expression
Clarify Question
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What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about histone acetyltransferases?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 16 – Control of Gene Expression
48. DNA methylation is the only known natural modification of DNA. It affects
49. If you were able to look very closely at a portion of DNA and find methylated histones,
you would
50. Elucidation of the histone code might
Chapter 16 – Control of Gene Expression
51. You are studying the function of a recently identified gene in C. elegans. You perform
genetic screens for several months in an attempt to isolate loss-of-function gene mutations,
but your efforts are unsuccessful. Your advisor suggests you try another approach to eliminate
gene function. The best technique to accomplish this goal would be
Chapter 16 – Control of Gene Expression
Clarify Question
•
What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about loss-of-function mutations?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
Chapter 16 – Control of Gene Expression
more desirable result?
52. The enzyme dicer chops dsRNA molecules into small pieces of
53. The gene encoding apolipoprotein B exists in two isoforms, APOB100 and APOB48.
These two forms are produced as a result of
54. Production of the iron-storing protein ferritin is regulated by aconitase, which binds to a
30-nucleotide sequence at the beginning of the ferritin mRNA and interferes with ribosome
binding. Aconitase must be a
Chapter 16 – Control of Gene Expression
Clarify Question
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about translational regulation?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 16 – Control of Gene Expression
55. What is the difference between a gene that is derepressed and one that is induced?
56. In your research, you have discovered that Protein X is often ubiquitinated in people with
a certain disease. What would you predict about levels of Protein X in these patients?
Chapter 16 – Control of Gene Expression
Clarify Question
•
What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about ubiquitination?
Consider Possibilities
•
What other information is related to the question? Which information is most useful?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 16 – Control of Gene Expression
57. You are studying the effects of specific transcription factors on the activation of gene
expression. You notice that one particular transcription factor binds far away from the
promoter of its target gene. What can explain this?
Chapter 16 – Control of Gene Expression
Clarify Question
•
What is the key concept addressed by the question?
•
What type of thinking is required?
•
What key words does the question contain and what do they mean?
Gather Content
•
What do you already know about transcriptional regulation?
Consider Possibilities
•
Consider the different answer options. Which can you rule out?
Choose Answer
•
Given what you now know, what information and/or problem solving approach is most
likely to produce the correct answer?
Reflect on Process
•
Did your problem-solving process lead you to the correct answer? If not, where did the
process break down or lead you astray? How can you revise your approach to produce a
more desirable result?
Chapter 16 – Control of Gene Expression
Check All That Apply Questions
58. Control of gene expression
59. Examples of shapes in regulatory proteins that are used to bind to DNA include
Chapter 16 – Control of Gene Expression
60. A bacterial gene regulatory system is likely have
61. Control of the lac operon and lactose utilization in bacteria is
62. The eukaryotic transcription initiation complex is
Chapter 16 – Control of Gene Expression
63. The ubiquitin-proteasome pathway
Multiple Choice Questions
64. Many factors bind around the core promoter to form the eukaryotic initation complex, but
the most important one is ______, which directly binds the TATA box.