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1. The perception that over-the counter drugs are safe can potentially result in serious consequences.
a. True
b. False
2. What is the most frequently used compound in the world?
a. Antihistamine
b. Acetaminophen
c. Ibuprofen
d. Aspirin
3. There is evidence that regular low dose aspirin use is associated with possible prevention of all of the following
EXCEPT
a. myocardial infarctions.
b. hemophilia.
c. breast cancer.
d. ovarian cancer.
4. An antipyretic would be most helpful in treating
a. stomach pain.
b. a headache.
c. a fever.
d. a swollen knee.
5. Aspirininterfereswithbloodclotting.
a. True
b. False
6. Which of the following does NOT have anti-inflammatory action?
a. Acetaminophen
b. Aspirin
c. Ibuprofen
d. Naproxen
7. Aspirin, in rare cases, can contribute to which of the following?
a. Depression
b. Hepatoxicity
c. Reye’ssyndrome
d. All of these answers
8. What over-the-counter analgesic is usually suggested for people with hypertension?
a. Acetaminophen
b. Aspirin
c. Ibuprofen
d. Naproxen
9. Which of the following analgesics are NOT advised for use by patients with a history of gastrointestinal bleeding,
unless ordered by a physician?
a. Acetaminophen
b. Aspirin
c. Ibuprofen
d. Naproxen
10. Which of the following over-the-counter analgesics are responsible for more than 100,000 overdoses each year, the
majority being unintentional?
a. Acetaminophen
b. Aspirin
c. Ibuprofen
d. Naproxen
11. Salicin
a. shares the harsh gastrointestinal side effects of its chemical cousin, salicylic acid.
b. is less irritating to the stomach than acetylsalicylic acid.
c. is about as irritating to the stomach than acetylsalicylic acid.
d. was introduced in 1898 as an analgesic by Bayer Pharmaceuticals.
12. It has been estimated that the annual worldwide consumption of aspirin is _______ doses.
a. 500 million
b. 50 billion
c. 500 billion
d. 700 million
13. The most commonly used agent for the control of fever around the world is
a. naproxen.
b. ibuprofen.
c. aspirin.
d. acetaminophen.
14. The use of aspirin in the treatment of myocardial infarction is most effective
a. if consumed in high doses.
b. if consumed in low doses.
c. when used with a diuretic agent.
d. when initiated in the first 48 hours of the attack.
15. A single dose of aspirin (325 mg) provides the same level of analgesia as
a. 5milligramsofDemerol®.
b. 15milligramsofDemerol®.
c. 100 mg of codeine.
d. 50 milligrams of meperidine.
16. Acetaminophen’sanalgesicpotentialisapproximately
a. twice that of aspirin.
b. equal to that of aspirin.
c. a quarter that of aspirin.
d. 50 percent higher than that of aspirin.
17. At the dosage levels suggested for ibuprofen as an over-the-counter agent (200-400 mg every 4 hours), this
compound’sanalgesiceffectsare
a. twice that of aspirin.
b. equal to that of aspirin.
c. a quarter that of aspirin.
d. 50percenthigherthanaspirin’sanalgesicpotential.
18. Which form of cyclooxygenase is required for normal body regulation?
a. COX-1
b. COX-2
c. COX-3
d. None of the above
19. Doses of acetaminophen higher than __________ are toxic to the liver.
a. 2,000 mg in 24 hours
b. 6,000 mg in 24 hours
c. 4,000 mg in 24 hours
d. 1,000 mg in 24 hours
20. The anti-inflammatory effects of ibuprofen
a. appear just as rapidly as those of aspirin.
b. are more rapidly achieved than those of aspirin.
c. require 3 days to begin to appear.
d. require 2-4 weeks of use to appear.
21. Naproxen’svalueintreatingheartattacks
a. is apparently either nonexistent or very limited.
b. is slower to appear than are the effects of aspirin.
c. isaboutthesameasaspirin’s.
d. requires co-administration of morphine.
22. Cumulative dose toxicity from acetaminophen
a. does not develop when used as directed.
b. can develop after just 10 days of use at recommended dosage levels.
c. does require that another protein bound substance be administered.
d. requires 10 days of constant use at higher-than-recommended dosage levels.
23. Aspirin is thought to be a factor in _______ of bleeding ulcers.
a. 10-20 percent
b. 40-50 percent
c. 20-41 percent
d. 8-12 percent
24. According to your text, more than 50 percent of acetaminophen overdoses are
a. unintended.
b. attempts at suicide.
c. intentional.
d. made by males.
25. To be fully effective in an acetaminophen overdose, N-acetylysteine must be administered within ___ of the time
the overdose was ingested.
a. 12 hours
b. 24 hours
c. 72 hours
d. 96 hours
26. Whywouldyourtextbookevenincludeachapteronoverthecounter(OTC)analgesics?
27. Howcanaspirinbebothgoodandbadforthecirculatorysystem?
28. Howdoesaspirindifferfornarcoticanalgesicsintreatingpain?
29. DescribesomeofthepotentialcomplicationsseenwithOTCanalgesicuse.
30. Discuss the possible effects of an overdose of acetaminophen.
