Chapter 13 The location of genetic information on chromosomes had been established

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Biology: A Guide to the Natural World, 5e (Krogh)

Chapter 13 Passing on Life’s Information: DNA Structure and Replication

1) The location of genetic information on chromosomes had been established beyond any doubt

by:

A) 1880.

B) 1850.

C) 1890.

D) 1920.

E) 1900.

2) Which of these individuals are credited with the discovery of the structure of DNA?

A) Rosalind Franklin and Maurice Wilkins

B) Gregor Mendel and T.H. Morgan

C) James Watson and Francis Crick

D) Louis Pasteur

3) Watson and Crick’s model of the structure of DNA was published in:

A) 1953.

B) 1961.

C) 1923.

D) 1949.

E) 1975.

4) Which information was determined about DNA based on X-ray diffraction data?

A) Each gene encodes one enzyme.

B) There are four different bases on the nucleotides.

C) Point mutations change a single location in the genome.

D) DNA has a helical structure.

E) Chromosomes are made of DNA.

5) How are X rays used in the technique of X-ray diffraction?

A) The scattering of X rays by a purified form of a molecule reveals its structure.

B) DNA strands are separated by X-ray energy, revealing the order of bases.

C) Cells are broken open to release chromosomes by being bombarded with X rays.

D) The X rays are used to mutate DNA to determine the location of genes.

E) Enzymes are destroyed by X rays, revealing the order of steps in metabolism.

6) It was primarily the X-ray diffraction work on DNA done by ________ that allowed Watson

and Crick to deduce the structure of DNA.

A) Louis Pasteur

B) Gregor Mendel

C) Rosalind Franklin

D) T.H. Morgan

7) Watson and Crick discovered:

A) the structure of DNA.

B) that DNA is the genetic material.

C) X-ray crystallography.

D) that genetic information resides on chromosomes.

8) Why are the strands of DNA said to be complementary to each other?

A) The sugar-phosphate chains are running in opposite directions.

B) The sugar-phosphate chains of each strand are identical.

C) Both strands can have any of four possible bases attached.

D) All the bases of one strand are paired up with their complementary bases on the other strand.

9) Which of the following is not a component of DNA nucleotides?

A) deoxyribose

B) a phosphate group

C) adenine

D) arginine

E) guanine

10) How is the information that specifies a protein stored in DNA?

A) in the arrangement of the sugar-phosphate chain

B) in the types of chemical bonds holding bases together

C) in the sequence of bases

D) in the orientation of the double strands

11) The building blocks of DNA are:

A) amino acids.

B) enzymes.

C) phosphate groups.

D) nucleotides.

E) bases.

12) What is the relationship between DNA and proteins?

A) Genes are made of proteins that encode the base sequence of DNA.

B) DNA stores the information needed to make proteins.

C) DNA makes up the individual sugar-phosphate-base units of a protein.

D) DNA molecules are the enzymes that synthesize proteins.

E) Proteins store the information needed to make DNA.

13) What is one way that incorrect nucleotides are removed from a newly synthesized molecule

of DNA?

A) Crossing over replaces regions with DNA errors with new segments of DNA.

B) DNA ligases both remove and replace incorrectly positioned nucleotides.

C) Any DNA strand with an error is destroyed, and an entire new strand is synthesized.

D) DNA polymerases remove incorrect nucleotides and replace them with correct ones.

E) DNA ligases remove incorrect nucleotides for replacement by DNA polymerases.

14) Imagine that the DNA replication error rate for a strain of bacterium that has a defective

repair mechanism is 1 in 10 million. If the cell’s genome is 5 million nucleotide pairs, how often

will the genome sustain a mutation in this strain, keeping in mind that both strands of a DNA

molecule are replicated at once?

A) once every five cell divisions

B) once per cell division

C) twice per cell division

D) four times per cell division

E) once every ten cell divisions

15) What is the function of DNA polymerase?

A) synthesizing nucleotides from free sugars, phosphates, and bases

B) halting DNA replication if a cell becomes cancerous

C) breaking sugar-phosphate bonds to release free nucleotides for DNA synthesis

D) introducing mutations into DNA for evolutionary adaptation

E) joining together nucleotides as they are base-paired during DNA replication

16) Which of the following statements about the two strands of a DNA molecule is true?

A) An A base on one strand always pairs with a G base on the other strand.

B) The strands are a pair of sister chromatids.

C) The strands are connected to each other by sugar-phosphate bonds.

D) A T base on one strand always pairs with an A base on the other strand.

E) The strands have identical base sequences.

17) What is meant by saying one strand of DNA is the template for the synthesis of another

strand?

A) A strand of DNA is taken apart to supply nucleotides for synthesis of a new strand.

B) One strand of DNA acts as a wedge to separate other strands before replication.

C) The template specifies the order of bases of the strand being made.

D) The new strand will have exactly the same base sequence as the template strand.

E) A strand of DNA is the enzyme that connects nucleotides in replication.

18) What are the products of the replication of one DNA molecule?

A) four identical double-stranded DNA molecules

B) two strands joined into one double-stranded DNA molecule

C) two identical double-stranded DNA molecules

D) a set of four sister chromatids

E) a pair of homologous chromosomes

19) How many different types of bases are used to encode all the genetic information in a

molecule of DNA?

A) 2

B) 4

C) 20

D) 10

E) 5

20) The nucleotides in one strand of DNA are held together by:

A) bonds between the sugar of one nucleotide and the base of the next.

B) hydrogen bonds between phosphates.

C) bonds between the phosphate of one nucleotide and the base of the next.

D) hydrogen bonds between complementary bases.

E) links between the sugar of one nucleotide and the phosphate of the next.

21) A base pair is a unit of DNA that consists of:

A) one sugar bonded to one phosphate.

B) a single chromosome.

C) one nucleotide.

D) two nucleotides, one on each complementary strand of a DNA molecule.

E) two identical chromosomes.

22) What happens to the two original strands of a DNA molecule after the DNA has replicated?

A) After serving as replication templates, the two original strands are rejoined.

B) After serving as replication templates, the two original strands are destroyed.

C) Nucleotides from the original strands are randomly incorporated into the new strands.

D) Incomplete segments of the original strands end up in each newly synthesized strand.

E) Each original strand ends up paired with a newly synthesized strand.

23) The two strands of a double helix of DNA are linked by what kind of bond?

A) sugar-phosphate linkages

B) hydrogen bonds between bases

C) hydrogen bonds between sugars and phosphates

D) sugar-base linkages

E) base-phosphate linkages

24) If the sequence TCGTA was used as a template in DNA replication, what would be the

sequence of bases on the newly synthesized strand?

A) ATGCT

B) CTACG

C) AGCAT

D) GCATC

E) TCGTA

25) What is the complementary sequence for a segment of DNA with the sequence ACGGCT?

A) TCGGCA

B) AGCCGT

C) TGCCGA

D) ACGGCT

E) GTAATC

26) In DNA, A, C, G, and T are abbreviations for the:

A) different types of bases on the nucleotides.

B) different types of sugars on the nucleotides.

C) types of genes found on DNA chromosomes.

D) different types of bonds that form between nucleotides.

E) different types of phosphates on the nucleotides.

27) The three components of a DNA nucleotide are:

A) amino acids, phosphates, and deoxyribose.

B) bases, deoxyribose, and polymerases.

C) genes, sugars, and bases.

D) phosphates, sugars, and bases.

E) polymerases, ligases, and sugars.

28) A key part of DNA’s function is to encode information. In considering how information-rich

a particular molecule might be, a question is how many different sequences are possible in a

particular length of the molecule. In the case of DNA the four different nucleotides can be

arranged in any order. How many different sequences are possible for a DNA strand three

nucleotides long?

A) 4

B) 32

C) 16

D) 64

E) 3

29) A DNA molecule can be described as a twisted ladder. The ________ form the sides, and the

________ form the rungs.

A) base pairs; sugar-phosphate chains

B) sugars; phosphates

C) sugars; base pairs

D) sugar-phosphate chains; base pairs

30) There are two alleles for each gene in a cell. If each gene encodes for a particular protein,

what would make two alleles different from each other?

A) The sequence of bases in the DNA for each allele would be slightly different and would lead

to the production of slightly different proteins.

B) The sequence of bases in the DNA would be different for each allele, but they would result in

the production of identical proteins.

C) The sequence of bases in the DNA would be identical for each allele, but they would produce

very different proteins.

D) The sequence of bases in the DNA would be identical for each allele, but one would produce

a protein and the other would not.

31) The DNA of a cell is analyzed and found to contain 28 percent thymine. What percent of the

DNA would by cytosine?

A) 22 percent

B) 28 percent

C) 50 percent

D) 25 percent

32) The average mutation rate for DNA replication is 1 mutation for every 10 billion

(10,000,000,000) nucleotides of DNA replicated. Yet DNA polymerase makes a mistake during

replication at an average of 1 in 100,000 nucleotides. What does this say about DNA replication?

A) Most errors in DNA replication become mutations.

B) The base-pairing rules (A pairs with T and G pairs with C) prevent any mutations.

C) Cells are extraordinarily proficient at repairing errors made during DNA replication.

D) Cells recognize that a small fraction of mutations are beneficial to organisms and do not

repair those.

33) Cancer is a disease caused by mutations. Yet in most instances if one of your parents

tragically died from cancer, this does not put you at greater risk than a person whose parents do

not develop cancer. How can cancer be caused by mutations and yet not be heritable?

A) The mutations that cause cancer are special and cannot be passed on regardless of what type

of cell they occur in.

B) Most cancers arise from mutations in germ-line cells.

C) Most cancers arise from mutations in somatic cells.

D) Cancer-causing mutations are repaired in offspring but not in parents.

34) On average, if you examine 1 million human cells looking at a single gene, you’ll find one

cell with a mutation in that gene. If you were looking at a gene that could lead to cancer when

mutated, how many mutated copies of that gene would you find in a person? (Assume a person

contains 100 trillion [100,000,000,000,000] cells.)

A) 100,000,000

B) 1,000

C) 1,000,000

D) 10,000,000,000

E) 100

35) Mutations that occur in somatic cells are:

A) responsible for the appearance of human diseases such as sickle-cell anemia.

B) never harmful.

C) passed on to successive generations when they are incorporated into gametes.

D) not passed on to future generations.

E) always harmful.

36) Melanoma is a cancer that is frequently associated with a mutation in what gene?

A) in the IT15 gene

B) in the DNA polymerase gene

C) in the BRAF gene

D) in the Huntington gene

37) What is a point mutation?

A) a mutation that affects a single cell

B) a mutation in which one chromosome is lost

C) an error in DNA that is caused by malfunctioning of DNA ligase

D) a mutation found at a single base pair in the genome

E) a mutation that affects only one metabolic pathway

38) Which type of mutation will have the most impact from an evolutionary point of view?

A) a mutation in a somatic cell

B) a mutation in a liver cell

C) a mutation in a germ-line cell

D) a mutation in a brain cell

39) How do most mutations affect an organism?

A) Most mutations either are harmful, or they have no effect.

B) Most mutations will kill the organism.

C) Most mutations create cancerous cells.

D) Most mutations are beneficial and create a more adapted organism.

40) Which process changes, adds, or removes information from the genome?

A) mutation

B) DNA replication

C) genetic recombination

D) crossing over

E) cancer

41) What is the benefit of mutations?

A) They eliminate unneeded regions of chromosomes.

B) They increase the shuffling of existing genetic information.

C) They create cancerous cells, which grow faster than others.

D) They add new genetic information upon which evolution can act.

42) What is the cause of Huntington disease?

A) a somatic cell mutation that causes cells to proliferate without control

B) a mutation that results in defective DNA polymerase

C) loss of the chromosome with the gene for a blood protein

D) a mutation in which there are repeating groups of three nucleotides

E) a mutation that results in defective amino acid synthesis

43) What happens if an incorrect nucleotide is not removed and replaced by the cell’s DNA-

correcting machinery?

A) A point mutation has occurred.

B) The result is a chromosomal aberration.

C) The effect will be lethal, and the cell will die.

D) The cell will become cancerous.

E) The entire chromosome must be destroyed.

44) What is the difference between whole-chromosome aberrations and point mutations?

A) Point mutations are not permanent changes in the DNA; aberrations are permanent.

B) Aberrations are not permanent changes in the DNA; point mutations are permanent.

C) Point mutations are the loss of parts of chromosomes; aberrations are the loss of whole

chromosomes.

D) Point mutations affect a single base pair in the genome; aberrations affect a large section.

45) What is the relationship between mutations and cancer?

A) Cells do not require mutations to become cancerous but acquire them as they divide.

B) Cells lose the ability to mutate their DNA and evolve once they become cancerous.

C) Some mutations cause cells to lose control over cell division, resulting in cancer.

D) Any point mutation will cause a cell to start proliferating without control, resulting in cancer.

E) Only a mutation can stop a cell once it becomes cancerous.

46) What is one mechanism by which a mutation can cause melanoma?

A) by causing the accumulation of Huntington protein in melanocytes, which keeps them moving

through the cell cycle

B) by causing the accumulation of altered BRAF protein in germ-line cells

C) by the production of an altered BRAF protein that keeps melanocytes moving through the cell

cycle

D) by preventing the BRAF protein from being able to repair damaged DNA

47) A trinucleotide repeat refers to:

A) a nucleotide that is made of three subunits: a sugar, a phosphate, and a nitrogenous base.

B) a sequence of three nucleotides that repeats and can be involved in genetic diseases.

C) the same nucleotide repeating three times in a row.

D) a nucleotide that contains three bases.

48) Any agent that can change the base sequence of DNA is known as a:

A) trinucleotide repeat.

B) free radical.

C) cancer.

D) mutagen.

E) spontaneous event.

49) Which of the following would be considered an environmental mutagen?

A) free radicals

B) ultraviolet light

C) spontaneous events

D) the collision of water molecules with DNA

E) DNA replication errors

50) The structure of a molecule can be revealed by bombarding it with X rays.

51) Watson and Crick’s experiments involved isolating DNA, generating X-ray diffraction

images of the DNA, and building a model of its structure.

52) The structure of DNA allows the molecule to store information.

53) Base-pairing rules apply from one DNA strand to its partner, but not along the sugar-

phosphate “handrails” of a DNA strand.

54) The structure of DNA allows the molecule to replicate itself.

55) The structure of DNA allows repair of simple damage.

56) DNA polymerase cannot copy point mutations, so they are not passed on from parent cells to

daughter cells in cell division.

57) Errors never occur in DNA replication because the DNA polymerases edit out mistakes.

58) Most point mutations have immediate, drastic effects on an organism.

Match the following.

A) nucleotides

B) bases

C) sugar-phosphate chain

D) thymine

E) cytosine

59) Adenine always base-pairs with this.

Topic: Section 13.3