The herpes viruses are important enveloped DNA viruses that cause disease in
vertebrates and in some invertebrates such as oysters. Some of the human forms are
herpes simplex virus (HSV) types I and II, causing facial and genital lesions, and the
varicella zoster virus (VSV), causing chicken pox and shingles. Each of these three
actively infects nervous tissue. Primary infections are fairly mild, but the virus is not
then cleared from the host; rather, viral genomes are maintained in cells in a latent
phase. The virus can later reactivate, replicate again, and infect others.
In electron micrographs of HSV infection, it can be seen that the intact virus initially
reacts with cell surface proteoglycans, then with specific receptors. This is later
followed by viral capsids docking with nuclear pores. Afterward, the capsids go from
being full to being “empty.” Which of the following best fits these observations?
A) Viral capsids are needed for the cell to become infected; only the capsids enter the
nucleus.
B) The viral envelope is not required for infectivity, since the envelope does not enter
the nucleus.
C) Only the genetic material of the virus is involved in the cell’s infectivity, and is
injected like the genome of a phage.
D) The viral envelope mediates entry into the cell, the capsid mediates entry into the
nuclear membrane, and the genome is all that enters the nucleus.
Most Swiss starlings produce four to five eggs in each clutch. Starlings producing fewer
or more than this have reduced fitness. Which of the following terms best describes this
situation?
A) directional selection