BISC 795 Test 2

subject Type Homework Help
subject Pages 7
subject Words 643
subject Authors Peter Parham

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page-pf1
C-reactive protein binds to _____.
a.phosphorylcholine
b.mannose-containing carbohydrates
c.lipoteichoic acid
d.flagellin
e.MASP-1/MASP-2.
All of the following processes occur in mature B cells after antigen encounter except
a.alternative splicing
b.affinity maturation
c.proliferation
d.somatic recombination
e.isotype switching.
page-pf2
Plasma cells have all of the properties listed except
a.they rapidly proliferate in secondary lymphoid follicles
b.they secrete antibody
c.they are terminally differentiated B cells
d.they no longer express MHC class II molecules
e.they cease expressing membrane-bound immunoglobulin
f.they differentiate into plasma cells after migration from germinal centers to other sites in
lymphoid tissue and bone marrow.
All of the following are highly polymorphic except
a.HLA-A chain
b.HLA-DO chain
c.HLA-B chain
d.HLA-DR chain
e.HLA-C chain.
Which of the following statements about human immunodeficiency virus (HIV) are
correct? (Select all that apply.)
page-pf3
a.HIV has a DNA genome.
b.HIV must synthesize reverse transcriptase immediately after infecting a cell.
c.HIV infects cells expressing CD4.
d.HIV requires the CXCR4 co-receptor for internalization by T cells.
e.NF B is a transcription factor that facilitates the transcription of proviral RNA.
The consequence of allelic exclusion at the immunoglobulin loci ensures that _____.
(Select all that apply.)
a.B-cell receptors have a low-avidity binding
b.B cells express antigen receptors of a single specificity
c.hybrid immunoglobulins are formed
d.all functional copies of a gene are expressed
e.homogeneous B-cell receptors bind more effectively to antigen.
A developing B cell unable to generate a productive rearrangement on any of the four
light-chain loci will undergo
a.self-renewal
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b.apoptosis
c.allelic exclusion
d.malignant transformation
e.differentiation into a B-1 cell.
Identify which of the following describes how antigen processing and presentation of self
antigens by thymic epithelial cells differs from that of antigen-presenting cells in
peripheral tissues. (Select all that apply.)
a.Thymic epithelium expresses MHC class I molecules but not MHC class II molecules.
b.Thymic epithelium uses cathepsin L for proteolytic degradation of self proteins.
c.Thymic epithelium expresses MHC class II molecules but not MHC class I molecules.
d.Thymic epithelium uses the transcription factor AIRE to activate thymic expression of
tissue-specific genes.
e.Thymic epithelium expresses transcription repressor protein FoxP3.
All of the following are examples of adjuvants except _____.
a.alum
b.MF59
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c.inactivated Bordetella pertussis
d.virosomes
e.RhoGAM.
Plasmacytoid dendritic cells _____. (Select all that apply.)
a.detect viral infection by using TLR4
b.produce large amounts of the type I interferons when activated
c.are found exclusively in the blood
d.make up 10% of circulating leukocytes
e.have a cytoplasmic morphology resembling that of antibody-producing plasma cells.
Genetic deficiencies in all of the following would impair the development of a fully
functional T-cell repertoire except
a.RAG-1 or RAG-2
b.Notch1
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c.Pax-5
d.IL-7 receptor (CD127)
e.TAP-1 or TAP-2.
In routine blood transfusions, which of the following must be matched correctly? (Select
all that apply.)
a.A and B antigens
b.O antigens
c.Rhesus D antigen
d.MHC class I molecules
e.MHC class II molecules.
Which of the three complement pathways becomes activated soonest after an initial
infection?
a.the classical pathway
b.the lectin pathway
c.the alternative pathway.

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