this by using two sets of liposomes. An anticancer drug (Doxorubicin (Dox)) bound to
DNA molecules was added into one set of liposomes (type A), and a high concentration
of ATP molecules were added to the other set of liposomes (type B). The drug is
inactive when bound to DNA molecules. Researchers inject both types of liposomes (A
and B) into cancer cells, and upon doing so their contents are released. The ATP
molecules (from liposome type A) bind to the DNA molecules (from liposome type B)
and activate the drug, thus inducing cell death and decreasing tumor size.
Mice with breast cancer tumors were treated with this liposome system to test the
effectiveness of the drug. The scientists performed three trials one with both types of
liposomes (Dox + ATP), one with just the drug (Dox only), and one with a salt solution
(control). Examine the figure below and answer the following questions.
Why did tumor size decrease in the Dox only experiment to a lesser extent than the Dox
+ ATP experiment?
A) ATP is actually the drug that is killing the cancer cells, not Dox.
B) Dox is always active in cancer cells, so it should be able to kill some cells without
ATP.
C) When ATP is lacking, not as much Dox can enter the cell via facilitated diffusion.
D) There is some ATP in the cancer cells normally, which acts to activate Dox.
Please read the following paragraph and answer the following questions.
Amanda’s parents realized that her body was not developing properly about the time she
was 12 years old. She was shorter than most of her friends and was not going through
changes normally associated with female puberty. They took her to a doctor who