When deficient, which of the following proteins does not render the individual more
susceptible to encapsulated bacteria?
a.C1INH
b.C3
c.Bruton’s tyrosine kinase
d.factor D
e.factor I
f.CD40 ligand.
With the exception of B cells, all other cells of the body have the immunoglobulin genes in
the
a.germline configuration
b.monoclonal form
c.recombined configuration
d.expressed configuration
e.chimeric form.
Identify three locations where secretory IgA can bind to antigens in mucosal tissue, and for
each give the fate of the antigen upon binding to secretory IgA.
Adoptive transfer of sipuleucel-T-primed dendritic cells is a form of immunotherapy
currently used for the treatment of _____.
a.late-stage metastatic prostate cancer
b.multiple myeloma
c.chronic myelogenous leukemia
d.melanoma
e.cervical cancer.
_____ express and contain granules containing inflammatory mediators. (Select
all that apply.)
a.macrophages
b.activated eosinophils
c.mast cells
d.natural killer cells
e.basophils.
Which of the following pairs is mismatched?
a.X-linked agammaglobulinemia: gamma globulin injections
b.X-linked hyper IgM syndrome: GM-CSF injections
c.X-linked hyper IgM syndrome: gamma globulin injections
d.hereditary angioedema: C1INH infusions
e.None of the above is mismatched.
A.Describe the different functions performed by the two subpopulations of NK cells in the
blood and how they are distinguished.
B.How does this compare with NK-cell subpopulations in other tissues?
Which of the following is not a characteristic of immunoproteasomes?
a.They make up about 1% of cellular protein.
b.They consist of four rings of seven polypeptide subunits that exist in alternative forms.
c.They are produced in response to IFN- produced during innate immune responses.
d.They produce a higher proportion of peptides containing acidic amino acids at the
carboxy terminus compared with constitutive proteasomes.
e.They contain 20S proteasome-activation complexes on the caps.
All of the following are included in the peptide-loading complex except
a.tapasin
b.calnexin
c.calreticulin
d.ERp57
e. -microglobulin.
Large pre-B cells undergo clonal expansion before the rearrangement of light-chain loci.
Which of the following are beneficial consequences of clonal expansion? (Select all that
apply.)
a.Autoreactive B cells are eliminated before the expenditure of energy needed to rearrange
a functional light-chain gene.
b.The energy used to make a functional heavy chain is not wasted as a result of the
inability to produce a functional light chain.
c.RAG gene expression is decreased, which in turn signals light-chain rearrangement.
d.A diverse population of immature B cells is generated that express the same chain but
a distinct light chain.
e.Approximately 85% of small pre-B cells will progress to the immature B-cell stage.
Bortezomib has all of the following effects except _____.
a.reducing the supply of peptides needed for MHC class I transport to the cell surface
b.inhibiting tumor-cell proliferation
c.inducing tumor-cell apoptosis
d.inhibiting proteasome activity
e.blocking inhibitory KIRs.