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Which of the following directly inhibits the cyclooxygenase pathway by inhibiting the
activity of prostaglandin synthase?
a.ADAM10
b.experimental anti-IgE
c.aspirin (acetyl salicylate)
d.chymotryptase
e.ADAM33.
All of the following are associated with superantigens except _____.
a.effective at minuscule concentrations
b.nonspecific activation of 2-20% of body's CD8 T cells
c.processing to peptides is not required for T-cell activation
d.massive production of IL-2, , and
e.activate T cells
f.provoke vomiting and diarrhea when ingested.
In terms of V, D, and J segment arrangement, the T-cell receptor -chain locus resembles
the immunoglobulin _______ locus, whereas the T-cell receptor -chain locus resembles
the immunoglobulin _______ locus:
a. light chain; light chain
b.heavy chain; light chain
c. light chain; heavy chain
d. light chain; heavy chain
e. light chain; light chain.
Talin is best described as a _____.
a.protein tyrosine kinase
b.transcriptional activator
c.cytoskeletal protein
d.pro-inflammatory cytokine
e.cytokine receptor that associates with Janus kinases (JAKs).
All of the following develop in the thymus except _____.
a. T cells
b. cells
c.NK cells
d.NKT cells
e.MAIT cells.
Amanda Chenoweth, 21 years of age, returned from a summer job as a pianist on a cruise
ship where she was exposed daily to excessive sun; she developed a rash on her cheeks.
She complained that her finger joints were stiff and painful, which made it difficult to play
the piano, and that her hips became painful after sitting at the piano for long periods. Her
blood sample tested positive for anti-nuclear antibodies and had decreased serum C3
levels. A urine albumin test showed elevated protein levels. A course of prednisone (an
anti-inflammatory steroid) in combination with naprosyn (a nonsteroidal
anti-inflammatory agent) was begun and her condition improved rapidly. What is the most
likely cause and clinical name of her condition?
a.deterioration of the central nervous system; multiple sclerosis
b.cartilage destruction by bone-cell enzymes; rheumatoid arthritis
c.immune complexes fixing complement in kidney, joints, and blood vessels; systemic
lupus erythematosus
d.autoantibodies against acetylcholine receptor at the neuromuscular junction; myasthenia
gravis
e.consumption of seafood to which she was allergic; acute systemic anaphylaxis.
All of the following events occur within germinal centers except
a.centrocytes mature from centroblasts
b.isotype switching
c.centroblasts arise from activated B ells
d.B cells are activated by CD4 helper T cells
e.affinity maturation
f.somatic hypermutation
g.production of memory B cells.
Which of the following is not produced by T follicular helper (TFH) cells?
a.CD4
b.IL-4
c.IFN-
d.TNF-
e.IL-21
