Campbell Biology, 10e (Reece)
Chapter 15 The Chromosomal Basis of Inheritance
1) When Thomas Hunt Morgan crossed his red-eyed F1 generation flies to each other, the F2
generation included both red- and white-eyed flies. Remarkably, all the white-eyed flies were
male. What was the explanation for this result?
A) The gene involved is on the Y chromosome.
B) The gene involved is on the X chromosome.
C) The gene involved is on an autosome, but only in males.
D) Other male-specific factors influence eye color in flies.
2) Which of the following is the meaning of the chromosome theory of inheritance as expressed
in the early twentieth century?
A) Individuals inherit particular chromosomes attached to genes.
B) Mendelian genes are at specific loci on the chromosome and, in turn, segregate during
meiosis.
C) No more than a single pair of chromosomes can be found in a healthy normal cell.
D) Natural selection acts on certain chromosome arrays rather than on genes.
3) Males are more often affected by sex-linked traits than females because _____.
A) male hormones such as testosterone often alter the effects of mutations on the X chromosome
B) female hormones such as estrogen often compensate for the effects of mutations on the X
chromosome
C) X chromosomes in males generally have more mutations than X chromosomes in females
D) males are hemizygous for the X chromosome
4) SRY is best described as _____.
A) a gene present on the X chromosome that triggers female development
B) an autosomal gene that is required for the expression of genes on the Y chromosome
C) a gene region present on the Y chromosome that triggers male development
D) an autosomal gene that is required for the expression of genes on the X chromosome
5) In cats, black fur color is caused by an X-linked allele; the other allele at this locus causes
orange color. The heterozygote is tortoiseshell. What kinds of offspring would you expect from
the cross of a black female and an orange male?
A) tortoiseshell females; tortoiseshell males
B) black females; orange males
C) tortoiseshell females; black males
D) orange females; black males
6) Red-green color blindness is a sex-linked recessive trait in humans. Two people with normal
color vision have a color-blind son. What are the genotypes of the parents?
A) XnXn and XnY
B) XNXN and XnY
C) XNXN and XNY
D) XNXn and XNY
7) Cinnabar eyes is a sex-linked, recessive characteristic in fruit flies. If a female having
cinnabar eyes is crossed with a wild-type male, what percentage of the F1 males will have
cinnabar eyes?
A) 0%
B) 25%
C) 50%
D) 100%
8) Normally, only female cats have the tortoiseshell phenotype because _____.
A) a male inherits only one allele of the X-linked gene controlling hair color
B) the Y chromosome has a gene blocking orange coloration
C) only males can have Barr bodies
D) multiple crossovers on the Y chromosome prevent orange pigment production
9) In birds, sex is determined by a ZW chromosome scheme. Males are ZZ and females are ZW.
A recessive lethal allele that causes death of the embryo is sometimes present on the Z
chromosome in pigeons. What would be the sex ratio in the offspring of a cross between a male
that is heterozygous for the lethal allele and a normal female?
A) 2:1 male to female
B) 1:2 male to female
C) 1:1 male to female
D) 3:1 male to female
10) Sex determination in mammals is due to the SRY gene. Which of the following could allow a
person with an XX karyotype to develop a male phenotype?
A) the loss of the SRY gene from an autosome
B) translocation of SRY to a X chromosome
C) a person with an extra autosomal chromosome
D) a person with one normal and one shortened (deleted) X
11) In humans, clear gender differentiation occurs, not at fertilization, but after the second month
of gestation. What is the first event of this differentiation?
A) formation of testosterone in male embryos
B) formation of estrogens in female embryos
C) activation of SRY in male embryos and masculinization of the gonads
D) activation of SRY in females and feminization of the gonads
12) Duchenne muscular dystrophy is a serious condition caused by a recessive allele of a gene on
the human X chromosome. The patients have muscles that weaken over time because they have
absent or decreased dystrophin, a muscle protein. They rarely live past their twenties. How likely
is it for a woman to have this condition?
A) Women can never have this condition.
B) One-fourth of the daughters of an affected man would have this condition.
C) One-half of the daughters of an affected father and a carrier mother could have this condition.
D) Only if a woman is XXX could she have this condition.
13) All female mammals have one active X chromosome per cell instead of two. What causes
this?
A) activation of the XIST gene on the X chromosome that will become the Barr body
B) activation of the BARR gene on one X chromosome, which then becomes inactive
C) inactivation of the XIST gene on the X chromosome derived from the male parent
D) attachment of methyl (CH3) groups to the X chromosome that will remain active
14) A man who is an achondroplastic dwarf with normal vision marries a color-blind woman of
normal height. The man’s father was six feet tall, and both the woman’s parents were of average
height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-
linked recessive. How many of their daughters might be expected to be color-blind dwarfs?
A) none
B) half
C) one out of four
D) three out of four
15) A man who is an achondroplastic dwarf with normal vision marries a color-blind woman of
normal height. The man’s father was six feet tall, and both the woman’s parents were of average
height. Achondroplastic dwarfism is autosomal dominant, and red-green color blindness is X-
linked recessive. What proportion of their sons would be color-blind and of normal height?
A) none
B) half
C) one out of four
D) all
16) Pseudohypertrophic muscular dystrophy is a human disorder that causes gradual
deterioration of the muscles. Only boys are affected, and they are always born to phenotypically
normal parents. Due to the severity of the disease, the boys die in their teens. Is this disorder
likely to be caused by a dominant or recessive allele? Is its inheritance sex-linked or autosomal?
A) dominant, sex-linked
B) recessive, autosomal
C) recessive, sex-linked
D) incomplete dominant, sex-linked
17) In birds, sex is determined by a ZW chromosome scheme that is much like the typical XY
scheme seen in humans and many other organisms, except that the system is reversed: Males are
ZZ (similar to XX in humans) and females are ZW (similar to XY in humans). A lethal recessive
allele that causes death of the embryo occurs on the Z chromosome in pigeons. What would be
the sex ratio in the offspring of a cross between a male heterozygous for the lethal allele and a
normal female?
A) 1:1 male to female
B) 3:1 male to female
C) 1:2 male to female
D) 2:1 male to female
18) A recessive allele on the X chromosome is responsible for red-green color blindness in
humans. A woman with normal vision whose father is color blind marries a color-blind male.
What is the probability that this couple’s first son will be color blind?
A) 1/4
B) 1/2
C) 2/3
D) 3/4
19) A man who carries an allele of an X-linked gene will pass it on to _____.
A) all of his daughters
B) half of his daughters
C) all of his sons
D) all of his children
20) Glucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as a recessive allele of
an X-linked gene in humans. A woman whose father suffered from G6PD marries a normal man.
(a) What proportion of their sons is expected to be G6PD?
(b) If the husband was not normal but was G6PD deficient, would you change your answer in
part (a)?
A) (a) 100%; (b) no
B) (a) 1/2; (b) yes
C) (a) 1/2; (b) no
D) (a) zero; (b) no
21) In a Drosophila experiment, a cross was made between homozygous wild-type females and
yellow-bodied males. All of the resulting F1s were phenotypically wild type. However, adult
flies of the F2 generation (resulting from matings of the F1s) had the characteristics shown in the
figure above. Consider the following questions:
(a) Is the mutant allele for yellow body recessive or dominant?
(b) Is the yellow locus autosomal (not X-linked) or X-linked?
A) (a) recessive; (b) X-linked
B) (a) recessive; (b) not X-linked
C) (a) dominant; (b) X-linked
D) (a) dominant; (b) not X-linked
22) Sturtevant provided genetic evidence for the existence of four pairs of chromosomes in
Drosophila in which of these ways?
A) There are four major functional classes of genes in Drosophila.
B) Drosophila genes cluster into four distinct groups of linked genes.
C) The overall number of genes in Drosophila is a multiple of four.
D) Drosophila genes have, on average, four different alleles.
23) Which of the following statements is true of linkage?
A) The closer two genes are on a chromosome, the lower the probability that a crossover will
occur between them.
B) The observed frequency of recombination of two genes that are far apart from each other has
a maximum value of 100%.
C) All of the traits that Mendel studied—seed color, pod shape, flower color, and others—are
due to genes linked on the same chromosome.
D) Linked genes are found on different chromosomes.
24) How would one explain a testcross involving F1 dihybrid flies in which more parental-type
offspring than recombinant-type offspring are produced?
A) The two genes are closely linked on the same chromosome.
B) The two genes are linked but on different chromosomes.
C) Recombination did not occur in the cell during meiosis.
D) Both of the characters are controlled by more than one gene.
25) What does a frequency of recombination of 50% indicate?
A) The two genes are likely to be located on different chromosomes.
B) All of the offspring have combinations of traits that match one of the two parents.
C) The genes are located on sex chromosomes.
D) Abnormal meiosis has occurred.
26) What is the definition of one map unit?
A) the physical distance between two linked genes
B) a 1% frequency of recombination between two genes
C) 1 nanometer of distance between two genes
D) the recombination frequency between two genes assorting independently
27) Recombination between linked genes comes about for what reason?
A) Nonrecombinant chromosomes break and then rejoin with one another.
B) Independent assortment sometimes fails.
C) Linked genes travel together at anaphase.
D) Crossovers between these genes result in chromosomal exchange.
28) What is an adaptive advantage of recombination between linked genes?
A) Recombination is required for independent assortment.
B) Recombination must occur or genes will not assort independently.
C) New allele combinations are acted upon by natural selection.
D) The forces on the cell during meiosis II results in recombination.
8
29) Map units on a linkage map cannot be relied upon to calculate physical distances on a
chromosome for which of the following reasons?
A) The frequency of crossing over varies along the length of the chromosome.
B) The relationship between recombination frequency and map units is different in every
individual.
C) Physical distances between genes change during the course of the cell cycle.
D) The gene order on the chromosomes is slightly different in every individual.
30) Between which two genes would you expect the highest frequency of recombination?
A) A and W
B) E and G
C) A and E
D) A and G
31) In a series of mapping experiments, the recombination frequencies for four different linked
genes of Drosophila were determined as shown in the figure above. What is the order of these
genes on a chromosome map?
A) rb–cn–vg-b
B) cn–rb-b-vg
C) b-rb–cn–vg
D) vg–cn-b-rb
Use the following information to answer the question(s) below.
A plantlike organism on the planet Pandora can have three recessive genetic traits: bluish leaves,
due to an allele (a) of gene A; a feathered stem, due to an allele (b) of gene B; and hollow roots
due to an allele (c) of gene C. The three genes are linked and recombine as follows:
A geneticist did a testcross with an organism that had been found to be heterozygous for the
three recessive traits and she was able to identify progeny of the following phenotypic
distribution (+ = wild type):
Phenotypes
Leaves
Stems
Roots
Number
1
a
+
+
14
2
a
+
c
0
3
a
b
+
32
4
a
b
c
440
5
+
b
+
0
6
+
b
c
16
7
+
+
c
28
8
+
+
+
470
Total
1000
32) Which of the following are the phenotypes of the parents in this cross?
A) 2 and 5
B) 1 and 6
C) 4 and 8
D) 3 and 7
33) Which of the progeny phenotypes will require recombination between genes A and B?
A) 1, 2, 5, and 6
B) 1, 3, 6, and 7
C) 2, 4, 5, and 8
D) 2, 3, 5, and 7
34) If recombination frequency is equal to distance in map units, what is the approximate
distance between genes A and B?
A) 3 map units
B) 6 map units
C) 15 map units
D) 30 map units
35) What is the greatest benefit of having used a testcross for this experiment?
A) The homozygous recessive parents are obvious to the naked eye.
B) The homozygous parents are the only ones whose crossovers make a difference.
C) The phenotypes of the progeny reveal the allelic content of the gamete from the heterozygous
parent.
D) All of the progeny will be heterozygous.
36) The greatest distance among the three genes is between a and c. What does this mean?
A) Gene c is between a and b.
B) Genes are in the order: a—b—c.
C) Gene a is not recombining with c.
D) Gene a is between b and c.
37) What is the reason that closely linked genes are typically inherited together?
A) They are located close together on the same chromosome.
B) The number of genes in a cell is greater than the number of chromosomes.
C) Alleles are paired together during meiosis.
D) Genes align that way during metaphase I of meiosis.
38) A homozygous tomato plant with red fruit and yellow flowers was crossed with a
homozygous tomato plant with golden fruit and white flowers. The F1 all had red fruit and
yellow flowers. The F1 were testcrossed by crossing them to homozygous recessive individuals
and the following offspring were obtained:
Red fruit and yellow flowers—41
Red fruit and white flowers—7
Golden fruit and yellow flowers—8
Golden fruit and white flowers—44
How many map units separate these genes?
A) 17.6
B) 15
C) 17.1
D) 18.1
39) In Drosophila melanogaster, vestigial wings are caused by a recessive allele of a gene that is
linked to a gene with a recessive allele that causes black body color. Morgan crossed black-
bodied, normal-winged females and gray-bodied, vestigial-winged males. The F1 were all gray
bodied, normal winged. The F1 females were crossed to homozygous recessive males to produce
testcross progeny. Morgan calculated the map distance to be 17 map units. Which of the
following is correct about the testcross progeny?
A) black-bodied, normal-winged flies = 17% of the total
B) black-bodied, normal-winged flies PLUS gray-bodied, vestigial-winged flies = 17% of the
total
C) gray-bodied, normal-winged flies PLUS black-bodied, vestigial-winged flies = 17% of the
total
D) black-bodied, vestigial-winged flies = 17% of the total
40) If cell X enters meiosis, and nondisjunction of one chromosome occurs in one of its daughter
cells during meiosis II, what will be the result at the completion of meiosis?
A) All the gametes descended from cell X will be diploid.
B) Half of the gametes descended from cell X will be n + 1, and half will be n – 1.
C) 1/4 of the gametes descended from cell X will be n + 1, 1/4 will be n – 1, and 1/2 will be n.
D) Two of the four gametes descended from cell X will be haploid, and two will be diploid.
41) One possible result of chromosomal breakage is for a fragment to join a nonhomologous
chromosome. What is this alteration called?
A) deletion
B) inversion
C) translocation
D) duplication
42) A nonreciprocal crossover causes which of the following products?
A) deletion only
B) duplication only
C) nondisjunction
D) deletion and duplication
43) Of the following human aneuploidies, which is the one that generally has the most severe
impact on the health of the individual?
A) 47, trisomy 21
B) 47, XXY
C) 47, XXX
D) 45, X
44) A phenotypically normal prospective couple seeks genetic counseling because the man
knows that he has a translocation of a portion of his chromosome 4 that has been exchanged with
a portion of his chromosome 12. Although his translocation is balanced, he and his wife want to
know the probability that his sperm will be abnormal. What is your prognosis regarding his
sperm?
A) 1/4 will carry the two normal chromosomes, 4 and 12, 1/4 will have only the two
translocation chromosomes and no normal chromosomes 4 and 12, and 1/2 will have both
normal and translocated chromosomes.
B) All will carry the same translocation as the father.
C) None will carry the translocation.
D) 1/2 will be normal and the rest will have the father’s translocation.
45) Abnormal chromosomes are frequently found in malignant tumors. Errors such as
translocations may place a gene in close proximity to different control regions. Which of the
following might then occur to make the cancer worse?
A) an increase in nondisjunction
B) expression of inappropriate gene products
C) a decrease in mitotic frequency
D) failure of the cancer cells to multiply
46) A couple has a child with Down syndrome. The mother is 39 years old at the time of
delivery. Which of the following is the most probable cause of the child’s condition?
A) The woman inherited this tendency from her parents.
B) The mother had a chromosomal duplication.
C) One member of the couple underwent nondisjunction in somatic cell production.
D) The mother most likely underwent nondisjunction during gamete production.
47) What is a syndrome?
A) a characteristic facial appearance
B) a trait that leads to cancer at some stage in life
C) a group of traits typically found in conjunction with a particular chromosomal aberration or
gene mutation
D) a specific characteristic that appears in conjunction with one specific aneuploidy
48) Which of the following is known as a Philadelphia chromosome?
A) a human chromosome 22 that has had a specific translocation
B) a human chromosome 9 that is found only in one type of cancer
C) an animal chromosome found primarily in the mid-Atlantic area of the United States
D) a chromosome found only in mitochondria
49) Which of the following is generally true of aneuploidies in newborns?
A) A monosomy is more frequent than a trisomy.
B) Monosomy X is the only viable monosomy known to occur in humans.
C) Human aneuploidy usually conveys an adaptive advantage in humans.
D) An aneuploidy resulting in the deletion of a chromosome segment is less serious than a
duplication.
50) A woman is found to have forty-seven chromosomes, including three X chromosomes.
Which of the following describes her expected phenotype?
A) a female with masculine characteristics such as facial hair
B) an apparent male who is sterile
C) healthy female of slightly above-average height
D) a sterile female
51) Which of the following is an example of monosomy?
A) Turner’s syndrome
B) Klinefelter’s syndrome
C) Down syndrome
D) trisomy X
52) Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C
nucleotides and chemical histone changes to silence a given gene. If this depends on the sex of
the parent who transmits the gene, which of the following must be true?
A) Genes required for early development stages must not be imprinted.
B) Methylation of this kind must occur more in males than in females.
C) Methylation must be reversible in ovarian and testicular cells.
D) The imprints are transmitted only to gamete-producing cells.
53) Correns found that the inheritance of variegated color on the leaves of certain plants was
determined only by the maternal parent. What phenomenon explains this pattern?
A) ribosome structure
B) chloroplast inheritance
C) genomic imprinting
D) sex-linkage
54) Mitochondrial DNA is primarily involved in coding for proteins needed for protein
complexes of the electron transport chain and ATP synthase. Therefore, mutations in
mitochondrial genes would most affect _____.
A) DNA synthesis in cells of the immune system
B) the movement of oxygen into erythrocytes
C) generation of ATP in muscle cells
D) the storage of urine in the urinary bladder
55) The pedigree in the figure above shows the transmission of a trait in a particular family.
Based on this pattern of transmission, the trait is most likely _____.
A) mitochondrial
B) sex-linked dominant
C) sex-linked recessive
D) autosomal dominant
56) A certain kind of snail can have a right-handed direction of shell coiling (DD or Dd) or left-
handed coiling (dd). However, if direction of coiling is due to a protein deposited by the mother
in the egg cytoplasm, then a Dd egg-producing snail and a dd sperm-producing snail will have
offspring of which genotype(s) and phenotype(s)?
A) 1/2 Dd:1/2 dd; all right-coiling
B) all Dd; all right-coiling
C) 1/2 Dd:1/2 dd; half right-coiling and half left-coiling
D) all Dd; half right-coiling and half left-coiling
57) During meiosis, a defect occurs in a cell that results in the failure of microtubules, spindle
fibers, to bind at the kinetochores, a protein structure on chromatids where the spindle fibers
attach during cell division to pull sister chromatids apart. Which of the following is the most
likely result of such a defect?
A) New microtubules with more effective binding capabilities to kinetochores will be
synthesized to compensate for the defect.
B) Excessive cell divisions will occur resulting in cancerous tumors and an increase in the
chromosome numbers known as polyploidy.
C) The defect will be bypassed in order to and ensure normal chromosome distribution in the
new cells.
D) The resulting cells will not receive the correct number of chromosomes in the gametes, a
condition known as aneuploidy.
58) Inheritance patterns cannot always be explained by Mendel’s models of inheritance. If a pair
of homologous chromosomes fails to separate during meiosis I, select the choice
that shows the chromosome number of the four resulting gametes with respect to the normal
haploid number (n)?
A) n+1; n+1; n-1; n-1
B) n+1; n-1; n; n
C) n+1; n-1; n-1; n-1
D) n+1; n+1; n; n