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Three investigatorsNsslein-Volhard, Wieschaus, and Lewiswon the Nobel Prize for
physiology and medicine in 1995 for work they did in 1970 with Drosophila. Briefly
describe their findings.
List two major differences between RNA and DNA at the level of the nucleotide.
The bicoid gene of Drosophila generates embryos with two posterior regions. What is
the likely aspect of embryonic development that the bicoid gene probably controls?
Can females display pattern baldness?
The catabolite repression system in E. coli essentially represses the lac operon when
glucose is present. What evolutionary advantage would favor evolution of such a
system?
Do Hox gene clusters exist in humans? If so, how many are known to exist?
List at least five of the assumptions that pertain to a population in a Hardy-Weinberg
equilibrium.
Provide a brief definition for positive interference.
Name two human traits that would be expected to have high concordance.
What represents an organism's genome?
Briefly describe what is meant by the term autoradiography and identify a classic
experiment that used autoradiography to determine the replicative nature of DNA in
eukaryotes.
Recent discoveries on causes of fragile X syndrome, myotonic dystrophy, and
Huntington disease indicate which type of genetic alteration?
Some restriction enzymes cleave DNA in such a manner as to produce blunt ends. Most
often ligation of blunt end fragments is enhanced by the use of the enzyme terminal
deoxynucleotidyl transferase. Speculate on the function of deoxynucleotidyl transferase
in terms of using blunt end fragments in cloning.
What is the name of the precursor molecule used in nucleic acid synthesis?
To estimate how much the means of a variety of like samples drawn from the same
population might vary, what statistic is often used and what is the formula for it?
What three possible models were suggested to originally describe the nature of DNA
replication?
What is polycistronic mRNA?
In what way are specific DNA sequences of the template amplified in the polymerase
chain reaction? In other words, how does one target the target?
How do segment polarity genes relate to pair-rule genes?
Cytochrome c is a respiratory pigment found in the mitochondria of eukaryotes.
Compared with some other proteins, it has changed very slowly over long periods of
time. Why?
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