Spherical regions in lymph nodes containing areas that are packed densely with
proliferating B cells are called _____.
a.efferent vessels
b.germinal centers
c.red pulp zones
d.periarterial lymphoid sheaths
e.medullary sinuses.
IgM is particularly efficient at fixing complement because it _____.
a.is a much larger antibody than the other isotypes
b.has an extra CH domain
c.is made first in an immune response and therefore has first access to C1q
d.has five binding sites for C1q
e.has easy access to extravascular areas.
The underlying molecular basis for distinguishing blood-group antigens A, B and O is
_____ at the erythrocyte surface.
a.the presence or absence of fucose in glycolipids
b.differences in the oligosaccharide attached to the lipid ceramide
c.structural polymorphisms in the Rhesus D antigen
d.the levels of MHC class I and class II molecules.
Naive B cells are recognized by their expression of
a.no immunoglobulins on the cell surface because somatic recombination has not yet
commenced
b.both membrane-bound and secreted forms of immunoglobulin
c.both IgM and IgD on the cell surface
d.V(D)J recombinase
e.uracil-DNA-glycosylase (UNG).
An adaptor protein in the inflammasome is required to link _____ to the NOD-like
receptor NLRP3.
a.MyD88
b.procaspase-1
c.RIPK2
d.TAKI
e.IKK.
A.Are the criteria for selecting suitable donors the same for liver and bone marrow
transplants?
B.Why or why not?
Extravillous trophoblast cells do not express _____. (Select all that apply.)
a.HLA-A
b.HLA-B
c.HLA-C
d.HLA-E
e.HLA-F
f.HLA-G
g.HLA class II.
Jenny O’Mara was five months pregnant when she stepped on a rusty piece of scrap metal
while hauling rotted wood from a dilapidated shed in her garden. The sliver of metal cut
through her sneaker and pierced her heel deeply. Her physician gave her a tetanus booster.
When Jenny’s baby was born she decided to breastfeed. If the baby’s antibodies were tested
for specificity to tetanus 2months after birth, what would be the expected finding?
a.the presence of anti-tetanus toxoid IgA antibodies
b.the presence of anti-tetanus toxoid IgM antibodies
c.the presence of anti-tetanus toxoid IgG antibodies
d.the presence of IgM antibody specific for Clostridium tetani cell-wall components
e.the presence of IgG antibody specific for Clostridium tetani cell-wall components.
Identify the mismatched pair.
a. TFH cells: Bcl6
b. TH1: GATA3
c. TH1 cells: IFN-\gamma
d. TH2: IL-4
e. Treg: TGF-\beta
When describing the various components of the vesicular system, which of the following
is not included?
a.nucleus
b.Golgi apparatus
c.endoplasmic reticulum
d.exocytic vesicles
e.lysosomes.