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Celiac disease exhibits all of the following symptoms except _____.
a.villous atrophy
b.anemia
c.diarrhea
d.tissue ulceration
e.malabsorption
f.increased susceptibility to intestinal cancer.
All of the following are examples of chemical barriers of innate immunity except _____.
a.lactic acid
b.normal microbiota
c.lysozyme
d.fatty acids
e.proteases.
Cross-priming of the immune response occurs when _____. (Select all that apply.)
a.viral antigens are presented by MHC class I molecules on the surface of a cell that is not
actually infected by that particular virus
b.cytosol-derived peptides enter the endoplasmic reticulum and bind to MHC class II
molecules
c.phagolysosome-derived peptides bind to MHC class II molecules
d.peptides of nuclear or cytosolic proteins are presented by MHC class II molecules.
A _____ antibody is one that facilitates a chemical reaction involving the antigen to which
it binds and interacts.
a.conformational
b.multivalent
c.catalytic
d.hypervariable
e.monoclonal.
Owing to the location of the -chain locus of the T-cell receptor on chromosome 14, if the
_______-chain locus rearranges by somatic recombination, then the -chain locus is
_______:
a. ; also rearranged
b. ; deleted
c. ; transcribed
d. ; deleted
e. ; also rearranged.
All hematopoietic stem cells express
a.CD34
b.CD127
c.CD19
d.VpreB 5
e.Pax-5
Which of the following does not activate complement? (Select all that apply.)
a.IgG1
b.IgG2
c.IgG3
d.IgG4
e.IgA
f.IgE
g.IgM
h.IgD.
Measurement of which of the following is commonly used when monitoring patients with
autoimmune diseases as an indicator of inflammatory relapse?
a.IL-1RA
b.cryopyrin
c.C-reactive protein
d.proIL-1\beta
e.IL-15.
The following cytokines activate NK cells early in the course of a viral infection with the
exception of _____.
a.IFN-\alpha
b.IFN-\beta
c.IFN-\gamma
d.IL-12
e.IL-15.
For infectious HIV virions to be made, the infected cell must _____. (Select all that apply.)
a.be CD4-positive
b.express low levels of CCR5
c.express functional NFkB
d.be latent
e.be polyreactive.
When the immune system is involved in _____, an appraisal for cancer cells is occurring.
a.malignant transformation
b.apoptosis
c.antineoplasia
d.immunosurveillance
e.immunosuppression.
All of the following are biological effects mediated by the products of mast cells except
_____.
a.chemotaxis of neutrophils, eosinophils, and effector T cells
b.growth factor secretion
c.smooth muscle contraction
d.connective tissue remodeling
e.All of the above are mediated by mast cells.
Which of the following is not mediated by antibodies?
a.type I hypersensitivity
b.type II hypersensitivity
c.type III hypersensitivity
d.type IV hypersensitivity.
All of the following are characteristic of NK cells except _____.
a.they express Toll-like receptors
b.they are tolerant of healthy cells
c.they circulate in a partly activated state
d.they all express the same selection of activating and inhibitory NK-cell receptors
e.they can be activated by Fc³RIIIA (CD16a).
The release of lytic granules from cytotoxic T cells is aimed specifically at infected target
cells while preserving the integrity of neighboring, uninfected cells. This is best explained
by the observation that _____.
a.only target cells bearing appropriate peptide:MHC class I complexes are susceptible to
necrosis
b.redistribution of lytic granules in the T cell delivers them to confined areas on the target
cell in contact with the T cell
c.regulatory T cells deliver survival signals to uninfected neighboring cells that renders
them resistant to cytotoxins
d.the amount of cytotoxins in a given cytotoxic T cell is so limited that only the cell closest
to the T cell will succumb to the effects of perforin and granzyme
e.uninfected cells are highly resistant to the effects of cytotoxins.
