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83) If pathogenic microorganisms are all around us, including in the air, on surfaces, and even on
our own skin, explain why we don’t all develop new infectious diseases every day.
Answer: Three conditions must be present at the same time to develop disease from exposure to
a microorganism.
1) The agent must be able to transmit the pathogen. In other words, there must be contact—
through broken skin, inhalation, and so forth—between the pathogen and the interior of the
human body. Skin, for example, is the body’s first defense: pathogens can gain entry to the body
2) The host must be susceptible; that is, vulnerable in some way to the infection. Most obviously,
the host‘s body temperature, chemistry, and cellular make-up must be hospitable to the pathogen
involved. This explains why, for example, a certain type of influenza that is pathogenic in dogs
may not be pathogenic in humans. Moreover, within any given community, some people have a
strong immune system, whereas others—including the very young, the very old, pregnant
women, and people who are ill—have a compromised immune system unable to destroy the
3) The environment must allow for the pathogen’s survival. Factors such as temperature, light,
and moisture must be hospitable to the pathogen. Pathogenic microorganisms in contaminated
foods cannot reproduce in your freezer, for example, but can replicate quickly in the same food
left out on your kitchen counter.
Skill: Analyzing
Section: The Process of Infection
Learning Outcome: 13.1