Running Head: PRADER-WILLI SYNDROME
Prader-Willi Syndrome
Nukpoafe Francis
Excelsior College
PRADER-WILLI SYNDROME 2
Abstract
Prader-Willi syndrome is a genetic disorder caused by the deletion or loss of function of genes
on segment 11-13 of paternal chromosome 15. Genes on chromosome 15 are either deleted,
turned off or silenced by processes such as DNA methylation and mutations. This paper
discusses PWS, its clinical manifestations, diagnosis, treatment, molecular basis and prevalence
using an extensive review of available literature. Symptoms of Prader-Willi syndrome vary from
one individual to another but generally include hypotonia, lethargy, poor responses, poor
suckling, feeding difficulties, and poor reflexes, learning disabilities and intellectual impairment,
