Ribivirin – inhibits DNA and RNA synthesis
• Tons of side effects
Better to use combination therapy for better results
Almost impossible for us to create new things, so we should try to make things better
Midterm – one or two keys issues
Introduction – why you picked a particular topic
Monday, 3/9/20
Guest Speaker – Jar-How Lee
• Transplants – solid organ, bone marrow, cord blood, compatible donor – blood group and
HLA
• How to increase odds of compatibility
• Allogeneic – donor
• Autologous – self
• Complement Dependent Cytotoxicity Assay (CDC)
• HLA – Human Leucocyte Antigen
o Most polymorphic gene cluster in human genome
o Role: defend yourself?
• Hyper-acute rejection –
• “Sensitizing Events” can lead to anti-HLA antibody
• Major Histocompatibility Complex (MHC)
• NGS Sequencing Platforms
o Illumina – highest accuracy but short fragment
o Ion Torrent –
o PacBio
o Oxford Nanopore – 20% error rate
• More like the HLA accuracy, the more like the compatibility and success of organ or