rising obesity levels. Several studies offer retrospective or prospective estimates of the degree of
disease incidence that can be linked to obesity, and of the magnitude of associated direct medical costs.
The most common definitions of obesity are based on body mass index (BMI), defined as
weight in kilograms divided by height in meters squared. Obesity in adults is generally defined
as a BMI of 30.0 or greater, with BMI of 25.0–29.9 categorized as overweight.
Thompson et al present a dynamic model of the relationships between BMI and the risks
of five diseases linked with obesity: hypertension, hypercholesterolemia, type 2 diabetes
mellitus, CHD, and stroke. The model captures both direct and indirect effects of obesity on
health outcomes – obesity is a risk factor for hypertension, hypercholesterolemia, and diabetes,
which are themselves risk factors for CHD and stroke. Estimated using a variety of data sources
(including the National Health And Nutritional Examination Survey or NHANES, and the
Framingham Study), the model gives future risks of all five diseases, life expectancy, and
lifetime medical costs associated with the five diseases for men and women aged 35 to 64 years
in each of four representative BMI groups (“healthy” BMI of 22.5, “overweight” BMI of 27.5,
“obese” BMI of 32.5, and “severely obese” BMI of 37.5). BMI is assumed to be constant at its
initial value for all individuals, with other risk factors adjusted for each year of aging. Results
from the model demonstrate substantial increases in disease risk with increasing BMI. Relative
to the group with BMI of 22.5, risk of hypertension is 40%–60% higher in the overweight (BMI
27.5), and twofold higher in the obese (BMI 32.5). Lifetime risk of CHD is 41.8% in obese men
compared to 34.9% in the nonobese; for women, risk increases from 25% for the nonobese to
32.4% for the obese.