Homework assignment I
Name: Annie Nguyen Beach ID: 025541176 Date: 02/11/2021
Question 1
The type of DNA infection observed in the COVID-19 virus infected host cells is
double-stranded breaks (DSBs). The double-stranded gaps result in DNA infection from
environmental exposure to irradiation, ultraviolet light (UV), or other chemicals that create
adequate service area for the virus cells to develop and generate more infections. Double
strand breaks are identified as the most harmful DNA lesions that allow virus infections in
our bodies. Again, if left unprepared, the developing chromosome discontinuity often
results in death, which has been evident to members attacked by the COVID-19 virus.
The identification of double-strand breaks in the milieu of eukaryotic chromosomes is a
heavy task that creates more time for the virus to cause more damages. During this initial
meiotic division, the directed double-strand breaks remain covalently connected to DNA
breakage sites. Many DNA viruses eliminate several aspects of cellular DNA damage
response machinery necessary in maximizing their replications. COVID-19 viruses are a
diverse group of higher, single-stranded, enveloped, and positive-sense RNA viruses that
causes various economically significant illnesses affecting human beings.
Question 2
There are two main repairing mechanisms mentioned in the textbook: non-
homologous DNA enjoining (NHEJ) and homologous recombination.
Question 3
Non-homologous DNA enjoining (NHEJ) seems to be the primary mechanism in
DSBs repair in mammalian cells. NHEJ repair mechanism doesn’t need homology and
can efficiently rejoin DNA ends directly end to end. The double-strand breakages site
repair via NHEJ occurs in three steps, including terminal processing, end-binding, and
proteins that promote its success, including Xrs2p, Mre11p, and Rad51p.